{"product_id":"abcam-ab307781","title":"Abcam, ab307781, ioGlutamatergic Neurons TDP-43 M337V homozygous - Human iPSC derived cells","description":"\u003cp\u003eSize: 1000000Cells \/ vial \/ 5000000Cells \/ vial\u003cbr\u003e\nioGlutamatergic Neurons TDP-43 M337V homozygous - Human iPSC derived cells available to order. Wild type ioGlutamatergic Neurons (ab303447) form the genetically matched control for the ioGlutamatergic Neurons TDP-43 M337V homozygous disease model. - Concentration: 1 million cells\/vial or 5 million cells\/vial\u003cbr\u003e\nKey facts\u003cbr\u003e\nSpecies or organism:Human,\u003cbr\u003e\nForm:LiquidSee storage information\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWild type ioGlutamatergic Neurons (\u003cbr\u003e\nab303447\u003cbr\u003e\n) form the genetically matched control for the ioGlutamatergic Neurons TDP-43 M337V homozygous disease model. This physiologically-relevant isogenic pairing offers a powerful next generation model to study amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in research and drug discovery.\u003cbr\u003e\nioGlutamatergic Neurons TDP-43 M337V homozygous are ioGlutamatergic Neurons carrying a genetically engineered M337V mutation in the TARDBP gene, encoding TAR DNA binding protein 43 (TDP-43). ioGlutamatergic Neurons TDP-43 M337V homozygous have been reprogrammed from human iPSCs using opti-ox\u003cbr\u003e\ntechnology, a precise reprogramming technology.\u003cbr\u003e\nHuman stem cells, within days, convert consistently into mature, functional glutamatergic neurons providing a high quality human model for the study of ALS and FTD.\u003cbr\u003e\nioGlutamatergic Neurons TDP-43 M337V homozygous express pan-neuronal and glutamatergic markers TUBB3, MAP2 and VGLUT2 by day 11.\u003cbr\u003e\nThis disease model offers a fast and easy-to-use system for investigations into the impact of gene function on disease progression against an isogenic control.\u003cbr\u003e\nA heterozygous disease model is also available (\u003cbr\u003e\nab307782\u003cbr\u003e\nIn partnership with bit.bio\u003cbr\u003e\nKaryotype:\u003cbr\u003e\nNormal\u003cbr\u003e\nSeeding Density:\u003cbr\u003e\n30,000 cells\/cm\u003cbr\u003e\nSeeding compatibility:\u003cbr\u003e\n6-, 12-, 24-, 96- and 384-well compatible\u003cbr\u003e\nQuality control:\u003cbr\u003e\nICC and gene expression analysis\u003cbr\u003e\nResearch applications:\u003cbr\u003e\nAcademic research, Drug development, Neurotoxicology, Genetic screening (e.g. CRISPR screening).\u003cbr\u003e\nThis product is subject to limited use licenses from iPS Academia Japan Inc, TET Systems GmbH, ERS Genomics Limited and Sigma-Aldrich Co. LLC and is developed with Bit Bio patented technology. For full details of the licenses and patents please refer to our\u003cbr\u003e\nlimited use license and patent pages\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--196°C, Appropriate long-term storage conditions--196°C\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845057204393,"sku":"ab307781","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab307781","provider":"Iright","version":"1.0","type":"link"}