{"product_id":"abcam-ab308167","title":"Abcam, ab308167, Anti-Miz1 antibody [HL1548]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal Miz1 antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human ZBTB17.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL1548,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human ZBTB17. The exact immunogen used to generate this antibody is proprietary information.Q13105\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMiz1 also known as Zinc finger Miz1 is a transcription factor with a mass of around 87 kDa. It features multiple zinc finger domains allowing it to bind DNA directly. Miz1 is widely expressed in various tissues particularly in the nucleus of cells. Its function includes both activating and repressing gene transcription depending on the context. By modulating transcription Miz1 plays a critical role in cellular proliferation and differentiation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMiz1 interacts with other transcription factors and forms part of larger complexes that influence the expression of genes involved in cell cycle regulation. Frequently Miz1 associates with the Myc protein which modifies its activity allowing for tight control over its function. Through these interactions Miz1 regulates important genes that can tip the balance between cell survival and apoptosis.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of Miz1 integrates into the TGF-beta and MAPK signaling pathways. In the TGF-beta pathway Miz1 collaborates with Smads to regulate target genes that govern cell growth. Meanwhile in the MAPK pathway Miz1's interaction with Myc influences gene expression impacting cellular responses to external signals. These pathways support Miz1's role in controlling cell proliferation and stress responses.\u003cbr\u003e\nMiz1 demonstrates significant involvement in cancer and developmental disorders. Dysregulation of Miz1 can lead to uncontrolled cell proliferation contributing to oncogenesis. Miz1's interaction with Myc is particularly linked to its oncogenic potential affecting genes that drive tumor progression. Additionally mutations or alterations in Miz1 function can impact developmental processes suggesting its role in some congenital conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851833135273,"sku":"ab308167","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab308167","provider":"Iright","version":"1.0","type":"link"}