{"product_id":"abcam-ab308200","title":"Abcam, ab308200, Anti-Influenza A virus M2 (matrix protein) antibody [HL1856]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal M2 antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Recombinant fragment - Influenza A samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL1856,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Influenza A,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Influenza A Virus M2 Protein also known as M2 ion channel or matrix protein 2 plays an essential role in the viral life cycle. This protein has a mass of approximately 97 amino acids and is expressed on the envelope of the Influenza A virus. It functions as a proton-selective channel facilitating the acidification of the viral interior after the virus enters the host cell. This acidification process is important for the uncoating of the viral genome allowing subsequent replication of the virus in host cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe M2 protein from Influenza A virus participates in virus assembly budding and release. The protein operates as a tetramer creating a channel across the viral membrane. This channel is essential for the correct function and structure of the virus playing an important role in membrane fusion and release of the viral particles. It often works in conjunction with another matrix protein M1 which assists in stabilizing the integrity of the viral structure.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe M2 Influenza protein is integral to the viral replication and assembly pathway. It aligns with the function of the viral ribonucleoprotein complex and is significant in the viral entry and exit pathways. Additionally the connection to the M1 matrix protein highlights its coordinated role in facilitating the assembly and release of new virions from the infected cells emphasizing its necessity in productive viral replication.\u003cbr\u003e\nThe Influenza A virus M2 protein is directly related to the pathogenesis of seasonal influenza. Antiviral drugs like amantadine and rimantadine target this ion channel to disrupt viral replication. Resistance mutations in the M2 protein can influence the efficacy of these drugs impacting treatment outcomes. There is also a link with immune system responses where M2 interactions with other viral proteins can modulate host immune evasion mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851858006185,"sku":"ab308200","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab308200","provider":"Iright","version":"1.0","type":"link"}