{"product_id":"abcam-ab308222","title":"Abcam, ab308222, Anti-CHD2 antibody [HL2066]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal CHD2 antibody. Carrier free. Suitable for IHC-P, WB and reacts with Mouse, Human, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human CHD2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL2066,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human CHD2. The exact immunogen used to generate this antibody is proprietary information.O14647\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe CHD2 protein also known as Chromodomain-Helicase-DNA-binding protein 2 acts as an ATP-dependent chromatin remodeler. This protein has a mass of approximately 210 kDa. CHD2 is expressed in various tissues with higher expression levels noted in the brain and skeletal muscle. As a part of the chromatin remodeling family CHD2 plays a role in modifying the structure of chromatin to affect gene expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCHD2 contributes to DNA repair and transcription regulation by modifying chromatin structure. It is a part of the CHD family of chromatin remodelers which influences nucleosome positioning and accessibility. By facilitating transcription CHD2 impacts gene expression necessary for neural development and other processes. CHD2 functions as a monomer and does not form larger protein complexes.\u003cbr\u003e\nPathways\u003cbr\u003e\nCHD2 influences gene expression regulation and neural development. It plays a role in the transcriptional regulation pathway by interacting with chromatin to control the accessibility of transcription factors. The protein links with others like CHD3 and CHD4 within this pathway to coordinate chromatin conformation changes necessary for proper transcription processes.\u003cbr\u003e\nThe CHD2 protein relates to epileptic encephalopathy and neurodevelopmental disorders. Mutations in the CHD2 gene associate with these conditions affecting neurological function and development. CHD2 mutations often coexist with other genetic factors involving proteins like SCN1A contributing to the complex nature of these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851758162089,"sku":"ab308222","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab308222","provider":"Iright","version":"1.0","type":"link"}