{"product_id":"abcam-ab308261","title":"Abcam, ab308261, Anti-Arx antibody [EPR27481-32] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ARX antibody. Carrier free. Suitable for IHC-P, mIHC, WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27481-32,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Rat, Mouse,\u003cbr\u003e\nApplications:IHC-P, mIHC, Flow Cyt (Intra), ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Arx protein also known as Aristaless related homeobox is a transcription factor encoded by the ARX gene. Its molecular mass is approximately 55 kDa. Arx is mainly expressed in the brain and pancreas where it plays roles in development. The protein contains a homeobox domain which allows it to bind DNA and regulate transcription. In neurons Arx modulates the development and differentiation affecting various neuronal populations.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nArx influences the development of the central nervous system and pancreatic functions. Arx operates as part of a regulatory network that includes other transcription factors. It coordinates with these factors to manage the expression of genes required for neuronal subtype specification. In the pancreas Arx impacts the fate determination of endocrine cells particularly influencing alpha-cell development over beta-cell development.\u003cbr\u003e\nPathways\u003cbr\u003e\nArx is an important player in both the neuronal differentiation and endocrine development pathways. It interacts with proteins like Pax4 and Nkx2.2 within these pathways ensuring proper cell-type specification and differentiation. These pathways ensure the formation of diverse neuronal subclasses and appropriate distribution of endocrine cells in the pancreas.\u003cbr\u003e\nArx is associated with epilepsy and intellectual disability. Mutations in the ARX gene can lead to X-linked intellectual disability and contribute to the development of epilepsy. In both conditions Arx's interaction with proteins such as DCX (Doublecortin) and LIS1 is significant as these proteins are implicated in neuronal migration and cortical development. Hence alterations in Arx function can disrupt these processes leading to neurological disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851738009769,"sku":"ab308261","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab308261","provider":"Iright","version":"1.0","type":"link"}