{"product_id":"abcam-ab308507","title":"Abcam, ab308507, Anti-TNF Receptor I antibody [EPR26198-14] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TNF Receptor I antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26198-14,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Soluble TNF Receptor I + Fc Fragment also known as TNFRSF1A-Fc is a recombinant fusion protein with an approximate mass of 75 kDa. Mechanically this fusion protein acts by binding to tumor necrosis factor-alpha (TNF-α) inhibiting its activity and preventing interactions with cell surface TNF receptors. Soluble TNF Receptor I + Fc Fragment keeps the TNF-α activity in check by acting as a decoy receptor. It is expressed in various cells including immune cells and endothelial cells allowing it to modulate inflammatory responses effectively.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Soluble TNF Receptor I + Fc Fragment helps regulate immune and inflammatory responses. It functions by blocking the pro-inflammatory effects of TNF-α an element pivotal in the inflammatory process. By neutralizing TNF-α it prevents the recruitment and activation of immune cells and cytokines. This protein does not function alone; it works within larger protein complexes to execute its role in cellular communication and signal transduction.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis fusion protein plays a significant role in the NF-κB and apoptosis signal pathways. Within these pathways TNF-α is an important mediator whose activity is moderated by the presence of the Soluble TNF Receptor I + Fc Fragment. By inhibiting TNF-induced activation of NF-κB the fusion protein can influence processes related to cell survival and death. It is closely related to proteins such as IκB (inhibitor of NF-κB) showing how its activity can have downstream effects on a variety of signaling processes.\u003cbr\u003e\nSoluble TNF Receptor I + Fc Fragment is used therapeutically in conditions like rheumatoid arthritis and inflammatory bowel disease. These disorders involve high levels of TNF-α which contribute to excessive inflammatory responses. The fusion protein helps mitigate such conditions by decreasing the TNF-α activity which in turn lowers inflammation. Through these actions this target is also indirectly connected to the regulatory proteins involved in these disorders like interleukin-6 (IL-6) which can also influence the inflammatory process.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851833102505,"sku":"ab308507","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab308507","provider":"Iright","version":"1.0","type":"link"}