{"product_id":"abcam-ab308572","title":"Abcam, ab308572, Anti-SHB antibody [HL1455]","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal SHB antibody. Carrier free. Suitable for IHC-P, WB and reacts with Mouse, Human samples. Immunogen corresponding to Synthetic Peptide within Human SH2 domain-containing adapter protein B.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:HL1455,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Mouse, Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human SH2 domain-containing adapter protein B. The exact immunogen used to generate this antibody is proprietary information.Q15464\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe SHB protein also known as Src homology 2 domain-containing adapter protein B has a molecular mass of approximately 67 kDa. It functions as an adaptor protein mediating interactions between various signaling molecules. SHB facilitates signal transduction by forming connections between different proteins which can affect several cellular processes. This protein is expressed in a wide range of tissues including the liver pancreas and brain indicating its importance in multiple physiological contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSHB plays a role in cellular responses to external stimuli and is involved in processes such as cell growth differentiation and apoptosis. It is a component of signal transduction pathways and works in conjunction with other signaling molecules to modulate these processes. SHB often forms complexes with other proteins allowing it to integrate signals from different pathways and coordinate complex cellular responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nSHB participates in the MAPK\/ERK and PI3K\/AKT signaling pathways. These pathways are important for regulating cell survival growth and metabolism. SHB interacts with proteins like Grb2 and Sos within the MAPK\/ERK pathway modulating their activity and in turn influencing downstream signaling events. In the PI3K\/AKT pathway SHB associates with and modulates the activity of important mediator proteins further illustrating its integrative role in cellular signaling networks.\u003cbr\u003e\nThe dysregulation of SHB has been implicated in cancer and diabetes. In cancer SHB influences tumor progression and metastasis through its interactions with proteins like Src and PI3K which are critical in cancer biology. In diabetes altered SHB signaling affects insulin secretion and glucose metabolism linking it to diabetic pathophysiology. Understanding SHB's interactions in these diseases could provide insights into potential therapeutic targets.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851787358377,"sku":"ab308572","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab308572","provider":"Iright","version":"1.0","type":"link"}