{"product_id":"abcam-ab309130","title":"Abcam, ab309130, Anti-XPC antibody [EPR25076-9] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal XPC antibody. Carrier free. Suitable for WB, IHC-P and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25076-9,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe Xeroderma Pigmentosum Complementation Group C (XPC) protein is essential for the nucleotide excision repair (NER) mechanism repairing DNA damage. XPC with a molecular weight of approximately 125 kDa recognises and binds to damaged DNA that has bulky adducts. It is expressed in various human tissues with higher expression levels in proliferating cells and skin. XPC plays a critical role in DNA testing and maintenance making it vital for maintaining genome stability.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe XPC protein acts as a damage sensor within the NER pathway and functions as part of the XPC-HR23B complex. This complex identifies DNA helix distortions and signals for repair by recruiting other proteins to the damage site. XPC functions by unwinding the DNA and allowing necessary repair enzymes such as DNA helicases and nucleases to perform their functions. This repair process ensures that the DNA is intact and capable of proper transcription and cell replication.\u003cbr\u003e\nPathways\u003cbr\u003e\nXPC operates within the nucleotide excision repair pathway which is essential for removing a wide range of DNA lesions caused by ultraviolet (UV) irradiation and chemical agents. It operates in conjunction with proteins such as XPA RPA and the TFIIH complex to execute DNA repair. XPC is also linked to the global genomic repair sub-pathway of NER where it plays a leading role in identifying DNA damage across the entire genome.\u003cbr\u003e\nIneffective XPC function is associated with Xeroderma Pigmentosum (XP) a genetic disorder causing extreme sensitivity to UV light and increased skin cancer risk. Mutations in the XPC gene impede DNA repair efficiency leading to the accumulation of damage. XPC is also connected to skin cancer development as its malfunction can cause failure to repair UV-induced lesions. Other proteins like XPA and XPE also show connections to these disorders highlighting their critical roles in maintaining DNA integrity and preventing disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851781165225,"sku":"ab309130","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab309130","provider":"Iright","version":"1.0","type":"link"}