{"product_id":"abcam-ab312833","title":"Abcam, ab312833, Anti-TRIM67 antibody [EPR25994-6] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal TRI67 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat, Transfected cell lysate samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25994-6,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTRIM67 also known as Tripartite Motif Containing 67 is a protein encoded by the TRIM67 gene. It belongs to the tripartite motif (TRIM) family of proteins characterized by an N-terminal RING finger domain one or two B-box motifs and a coiled-coil region. TRIM67 has a molecular mass of approximately 53 kDa. This protein is mainly expressed in the brain particularly in neurons highlighting its importance in neural tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTRIM67 plays an important role in neuronal development and differentiation. It contributes to processes like axon outgrowth and guidance which are critical for proper neuronal network formation. TRIM67 does not function as part of a complex but interacts with other proteins for executing its roles. It is known to modulate several signaling pathways key to cell proliferation and survival emphasizing its importance in cellular maintenance and integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nTRIM67 impacts the regulation of the Wnt signaling pathway which is essential for numerous developmental processes. Moreover it has a relationship with the PI3K\/AKT signaling pathway which is important for cell growth and apoptosis. In these pathways TRIM67 can interact with proteins like DVL and AKT1 contributing to their regulation and overall pathway stability. This connectivity underlines the multifaceted role TRIM67 plays in cell signaling and developmental biology.\u003cbr\u003e\nTRIM67 has been associated with neurological disorders given its strong expression in neuronal tissues. Specifically it relates to conditions like autism spectrum disorders (ASD) where disruptions in its expression or mutations could impact neural connectivity. Additionally neurodegenerative diseases such as Alzheimer's disease may also involve TRIM67 due to its role in neuronal survival and function. These associations highlight a connection with proteins like APP and BDNF which are linked to neural health and disease.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851143073961,"sku":"ab312833","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab312833","provider":"Iright","version":"1.0","type":"link"}