{"product_id":"abcam-ab312839","title":"Abcam, ab312839, Anti-OATP1B1 antibody [EPR27070-49] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal OATP1B1 antibody. Carrier free. Suitable for WB, IHC-P, Dot and reacts with Human, Transfected cell lysate - Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR27070-49,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, Dot, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nOATP1B1 also known as SLCO1B1 is a solute carrier organic anion transporter protein with a mass of approximately 85 kDa. This protein operates mechanically by transporting endogenous compounds and xenobiotics such as drugs across liver cell membranes. The primary expression of OATP1B1 occurs in the liver specifically on the basolateral membrane of hepatocytes. This localization facilitates its essential role in hepatic uptake of a variety of substances playing a critical role in pharmacokinetics.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nOATP1B1 contributes prominently to drug metabolism and clearance. It actively transports diverse substrates including bile acids bilirubin and drugs such as statins. While not part of a larger complex OATP1B1 functions alongside other hepatic transporters to ensure efficient clearance and detoxification processes in the liver. The activity of OATP1B1 is fundamental for maintaining drug concentrations within therapeutic ranges thereby protecting against toxicity.\u003cbr\u003e\nPathways\u003cbr\u003e\nOATP1B1 is part of the hepatic drug metabolic pathway and the bile acid synthesis pathway. It works in coordination with other transporters like OATP1B3 and NTCP which also mediate hepatic uptake of organic anions and bile acids. The interaction among these transporters regulates the systemic levels of endogenous compounds and the clearance of therapeutic drugs influencing their efficacy and safety profiles.\u003cbr\u003e\nOATP1B1 is linked to altered drug metabolism leading to statin-associated myopathy. Genetic variations in the OATP1B1 gene can reduce transporter function resulting in increased plasma concentration of statins which correlates with myopathy risk. Additionally OATP1B1 mutations may affect bilirubin handling contributing to conditions such as Rotor syndrome. Through these associations OATP1B1 interacts with other proteins affecting drug safety and disease states emphasizing its relevance in personalized medicine.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851781722281,"sku":"ab312839","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab312839","provider":"Iright","version":"1.0","type":"link"}