{"product_id":"abcam-ab313410","title":"Abcam, ab313410, Anti-MMP16 antibody [RP23040073]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Recombinant Multiclonal MMP16 antibody. Suitable for IHC-P, ICC\/IF, WB, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human MMP16.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Multiclonal,\u003cbr\u003e\nClone number:RP23040073,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, IHC-P, ICC\/IF, Flow Cyt (Intra)See reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Fragment Protein within Human MMP16.P51512\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat are recombinant multiclonals?\u003cbr\u003e\nRecombinant multiclonals are a mixture of recombinant antibodies co-expressed from a library of heavy and light chains. They offer several advantages including:\u003cbr\u003e\n- The sensitivity of polyclonal antibodies by recognising multiple epitopes\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nView our range of\u003cbr\u003e\nrecombinant multiclonal antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMMP16 also known as MT3-MMP (membrane-type 3 matrix metalloproteinase) is an enzyme part of the matrix metalloproteinase family. It plays a mechanical role in the degradation of extracellular matrix components. MMP16 has a molecular mass of 66 kDa and has proteolytic activity that contributes to tissue remodeling processes. This protein is a membrane-bound enzyme expressed in several tissues including the brain lungs and placenta. In the central nervous system it aids in maintaining extracellular environment by breaking down proteins.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMMP16 is essential in facilitating cellular activities such as migration invasion and angiogenesis. This protein operates as part of a complex that activates other MMPs including pro-MMP2 boosting their enzymatic activity. MMP16 participates in cellular remodeling by regulating the interactions between cells and their matrix which influences cell signaling and tissue morphogenesis.\u003cbr\u003e\nPathways\u003cbr\u003e\nMMP16 integrates into pathways relevant to extracellular matrix remodeling and cell signaling. It is actively involved in the Wnt and MAPK signaling pathways which influence various biological processes including development and cell proliferation. MMP16 also shows interactions with other MMP family members like MMP2 and MMP14 which collectively modulate the local microenvironment and cellular dynamics.\u003cbr\u003e\nMMP16 is associated with cancer progression and neurodegenerative diseases. In cancer its upregulation correlates with tumor invasion and metastasis owing to its role in degradation of the basement membrane. MMP16 also contributes to neurodegenerative conditions like Alzheimer's Disease by affecting synaptic functions and neuron survival. It interacts with proteins like APP involved in Alzheimer's linking MMP16 to amyloid beta peptide processing and aggregation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850176254121,"sku":"ab313410","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab313410","provider":"Iright","version":"1.0","type":"link"}