{"product_id":"abcam-ab313504","title":"Abcam, ab313504, Human ADAMTS15 ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman ADAMTS15 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human ADAMTS15 in Human in Cell Culture Media, Biofluids samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Cell culture supernatant, Serum, Plasma,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 0.45 ng\/mL,\u003cbr\u003e\nRange:0.45 - 100 ng\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman ADAMTS15 ELISA kit is an\u003cbr\u003e\nin vitro\u003cbr\u003e\nenzyme-linked immunosorbent assay for the quantitative measurement of human ADAMTS15 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human ADAMTS15 coated on a 96-well plate.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nADAMTS15 also known as A Disintegrin And Metalloproteinase with Thrombospondin motifs 15 is a member of the ADAMTS family of zinc-dependent metalloproteases. It is involved in the degradation of extracellular matrix components especially proteoglycans. This protease has a mass of approximately 110 kDa. Researchers found ADAMTS15 expression mainly in cartilage and testis highlighting its tissue-specific roles. Understanding its mechanical role as a proteoglycanase gives insight into its contribution to tissue remodeling dynamics.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nADAMTS15 plays a significant role in extracellular matrix organization and turnover. It mediates proteolytic processing of aggrecan and other proteoglycans which are important for structural integrity in tissues like cartilage. It operates independently rather than as part of a complex. The proteolytic function of ADAMTS15 is essential in processes like embryonic development cell migration and angiogenesis emphasizing its influence in maintaining normal physiological functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nADAMTS15 is implicated in the proteoglycan turnover pathway and the Wnt signaling pathway. Its activities within these pathways contribute to cellular matrix degradation and regulation of cell growth and differentiation. ADAMTS15 associates with other proteins such as aggrecan and collagen that participate in matrix degradation. It shows functional similarities and interactions with other ADAMTS family members like ADAMTS4 and ADAMTS5 which further support its role in matrix dynamics.\u003cbr\u003e\nResearchers link ADAMTS15 with osteoarthritis and some forms of cancer. In osteoarthritis abnormal activity of ADAMTS15 leads to excessive degradation of cartilage matrix contributing to joint degeneration. Proteins like aggrecan targeted by ADAMTS15 play a role in this disorder. In cancer ADAMTS15 involvement appears in the regulation of tumor microenvironment dynamics and metastasis. Its interaction with structural components of the matrix makes it a potential therapeutic target in both contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855674691753,"sku":"ab313504","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab313504","provider":"Iright","version":"1.0","type":"link"}