{"product_id":"abcam-ab313598","title":"Abcam, ab313598, Human FABP6 ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman FABP6 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human FABP6 in Human in Cell Culture Media, Biofluids samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Cell culture supernatant, Plasma, Serum,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 1.64 ng\/mL,\u003cbr\u003e\nRange:1.64 - 400 ng\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman FABP6 (Fatty acid binding protein-6) ELISA kit is an\u003cbr\u003e\nin vitro\u003cbr\u003e\nenzyme-linked immunosorbent assay for the quantitative measurement of human FABP6 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human FABP6 coated on a 96-well plate.\u003cbr\u003e\nThis ELISA kit shows no cross-reactivity with the following cytokines tested: human ADAM22, Arylsulfatase B\/ARSB, B3GNT2, Carbonic Anhydrase VB, Caspase 7, Caspase 8, Integrin alpha M\/CD11b, SIRP gamma\/CD172g, CD39L2\/ENTPD6, CD39L4\/ENTPD5, Integrin alpha 2\/CD49b, CD7, CEACAM-3, Carboxypeptidase E\/CPE, FAM3C, GDF-3, GSTM1, Kallikrein 11, Kallikrein 12, Kremen-2, OSCAR, PTP1B, Reg3A, R-Spondin 2, S100A13, Semaphorin 4C, Sirtuin 1\/SIRT1, SMPD1, Sortilin, SPINK1, Stabilin-2, SULT2A1, Transcobalamin II, THSD1, TrkA, UCH-L3, VAPA, vWF-A2, Wnt-4.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nFatty acid-binding protein 6 (FABP6) also known as ileal bile acid binding protein (IBABP) plays a significant role in binding bile acids. This protein weighs approximately 14 kDa and is prominently expressed in the ileum of the small intestine. It functions primarily within the cytoplasm ensuring the transportation of bile acids to specific locations within cells. By doing this FABP6 facilitates the proper metabolism and absorption of these acids which are critical components for the digestion and absorption of dietary fats.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe protein plays a critical role in the enterohepatic circulation of bile acids which it binds with high affinity. FABP6 operates within a network of ligands and ions aiding in the homeostasis of bile acids. While it does not directly associate with larger complexes its action contributes to maintaining a balance of cholesterol and fats in the body. It also integrates with other fatty acid-binding proteins like FABP1 and FABP3 which engage in similar transport functions in different tissues.\u003cbr\u003e\nPathways\u003cbr\u003e\nFABP6 functions prominently within the bile acid signaling and lipid metabolism pathways. It interacts closely with proteins such as FXR (Farnesoid X receptor) that senses bile acid concentrations and regulates their synthesis and transport. Additionally FABP6 has relationship with the bile acid-CoA:amino acid N-acyltransferase (BAAT) which is involved in bile acid conjugation. These connections underpin its key role in lipid digestion and cholesterol homeostasis.\u003cbr\u003e\nFABP6 has associations with cholestasis and Crohn’s disease. In cholestasis impaired bile flow can arise from the dysfunction of bile acid transport to which FABP6 is linked. Furthermore alterations in the protein’s expression or function contribute to Crohn’s disease particularly in the ileal region where it heavily expresses. Mutations and malfunction of related proteins such as FXR and BAAT can complement or exacerbate these issues solidifying the importance of FABP6 in maintaining gut and liver health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843760902313,"sku":"ab313598","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab313598","provider":"Iright","version":"1.0","type":"link"}