{"product_id":"abcam-ab314355","title":"Abcam, ab314355, Human ST3Gal1 ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman ST3Gal1 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human ST3Gal1 in Human in Cell Culture Media, Biofluids samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Cell culture supernatant, Plasma, Serum,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 1.8 ng\/mL,\u003cbr\u003e\nRange:1.8 - 400 ng\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman ST3Gal1 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human ST3Gal1 in serum, plasma and cell culture supernatants. This assay employs an antibody specific for human ST3Gal1 coated on a 96-well plate.\u003cbr\u003e\nThis ELISA kit shows no cross-reactivity with the following cytokines tested: human C1qTNF9, Carbonic Anhydrase VA, CANT1, Cathepsin H, Contactin-5, Chymotrypsin C\/CTRC, Draxin, EphB2, EphB3, FABP8, Fgr, FKBP51, FUCA1, Galanin, GALNT10, Gastrokine 1, Glyoxalase II, HS3ST1, HS3ST3B1, Lin28, Lysyl Oxidase Homolog, LRRTM4, Methionine Aminopeptidase 1D, Matrilin-2, MCEMP1, Mcl-1, MDGA2, MEF2C, Methionine Aminopeptidase 2, Neurocan, Nogo-A, PCK1, PlGF-2, PON1, SALM4\/LRFN3, Semaphorin 6C, SorCS2, ST8SIA1, Tsukushi\/TSK.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nST3Gal I also known as ST3 beta-galactoside alpha-23-sialyltransferase 1 or sialyltransferase 1 is an enzyme with a molecular mass of approximately 35 kDa. This enzyme catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates specifically creating the sialyl T antigen. ST3Gal I is expressed in many tissues including the gastrointestinal tract lungs and the immune system reflecting its diverse roles in different physiological contexts.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nST3Gal I participates in glycosylation processes that modify proteins and lipids influencing cell-cell interactions immune responses and protein stability. It often associates with glycosylation complexes ensuring the proper addition of sialic acid to glycoconjugates. These modifications are critical for the formation of sialyated glycoconjugates which play significant roles in cellular communication and pathogen recognition.\u003cbr\u003e\nPathways\u003cbr\u003e\nST3Gal I impacts the sialylation pathway and by extension affects glycan biosynthesis pathways. It modifies glycoproteins and glycolipids which are important in cell adhesion and signaling pathways. Within these pathways ST3Gal I shows interactions with proteins involved in these processes such as those in the selectin family which mediate leukocyte trafficking.\u003cbr\u003e\nAltered ST3Gal I expression or activity links to certain cancers and immune disorders. Its dysregulation can lead to aberrant glycosylation patterns impacting processes like tumor metastasis and immune evasion. For instance the sialylation of mucins which influences tumor progression requires ST3Gal I. Also its interaction with other glycosyltransferases includes the regulation of immune cell surface antigens connecting it to autoimmune conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843757559977,"sku":"ab314355","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab314355","provider":"Iright","version":"1.0","type":"link"}