{"product_id":"abcam-ab314639","title":"Abcam, ab314639, Anti-ZC3H13 antibody [EPR25077-7] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal ZC3H13 antibody. Carrier free. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR25077-7,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab314639 is the carrier-free version of\u003cbr\u003e\nab314638\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nZC3H13 also known as zinc finger CCCH-type containing 13 is a protein with mass around 110 kDa. This protein is recognized for its role in post-transcriptional regulation of gene expression by mediating methylation of the N6 position of adenosine residues within RNA molecules. It possesses zinc finger motifs which allow it to bind to RNA and participate in RNA processing. ZC3H13 is expressed in various tissues including the liver lungs and brain indicating its widespread influence in physiological processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nZC3H13 functions as part of the m6A methyltransferase complex where it interacts with other proteins like METTL3 and METTL14. This complex modifies mRNA influencing its stability localization and translation efficiency. Through these actions ZC3H13 plays an important role in regulating RNA metabolism impacting numerous biological activities such as cellular differentiation and response to environmental stress.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe function of ZC3H13 integrates into both the mRNA processing and m6A methylation pathways. The protein maintains a strong link with RNA metabolism underpinning cellular processes critical for gene expression. In the pathways it associates with proteins like WTAP and KIAA1429 which coordinate to modulate mRNA methylation levels and stability therefore influencing gene expression patterns and cellular function.\u003cbr\u003e\nAbnormal function or expression of ZC3H13 is associated with cancer and developmental disorders such as acute myeloid leukemia. ZC3H13's activity is often altered in these conditions contributing to dysregulation of gene expression and uncontrolled cell growth. In cancer its connections with proteins like METTL3 play a role in oncogenic transformation highlighting its potential as a therapeutic target for intervention strategies aiming to modulate mRNA methylation and stabilize normal cellular functions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851744989353,"sku":"ab314639","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab314639","provider":"Iright","version":"1.0","type":"link"}