{"product_id":"abcam-ab314643","title":"Abcam, ab314643, Anti-NRDP1 antibody [EPR26281-19] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nKnockout Tested Rabbit Recombinant Monoclonal NRDP1 antibody. Carrier free. Suitable for WB, IP and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26281-19,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab314643 is the carrier-free version of\u003cbr\u003e\nab314642\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nNRDP1 also known as Neuregulin Receptor Degradation Protein 1 or FLJ11239 acts as an E3 ubiquitin ligase. It is a critical component for targeting certain proteins for ubiquitination and degradation processes. The protein has a molecular weight of approximately 36 kDa. Researchers have observed its expression in various tissues such as the brain heart and liver indicating its diverse role across different organ systems.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNRDP1 functions in regulating protein levels within cells by tagging them for degradation. It particularly associates with ErbB3 a member of the epidermal growth factor receptor (EGFR) family and induces its ubiquitination. This interaction reflects NRDP1’s role in controlling cell proliferation signaling. It is not part of any multiprotein complex but has shown the capacity to influence individual protein interactions.\u003cbr\u003e\nPathways\u003cbr\u003e\nResearchers identify NRDP1 as a participant in the ubiquitin-proteasome pathway and the ErbB signaling pathway. In the ubiquitin-proteasome pathway it facilitates the degradation of proteins to maintain cellular proteostasis. NRDP1 interacts with Parkin an E3 ubiquitin ligase associated with mitochondrial quality control. In the ErbB signaling pathway it modulates the function of ErbB receptors impacting cellular responses such as growth and differentiation.\u003cbr\u003e\nNRDP1 is implicated in cancer and neurodegenerative diseases. Its dysregulation may lead to improper ErbB3 signaling contributing to the development of certain cancers. Abnormal NRDP1 function correlates with neurodegenerative diseases like Parkinson's disease where it interacts with Parkin. These interactions suggest that NRDP1’s role in proteostasis and cell signaling can influence disease progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851753705641,"sku":"ab314643","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab314643","provider":"Iright","version":"1.0","type":"link"}