{"product_id":"abcam-ab314724","title":"Abcam, ab314724, Human Cystatin SA\/CST2 2 ELISA Kit","description":"\u003cp\u003eSize: 1 x 96Tests\u003cbr\u003e\nHuman Cystatin SA\/CST2 2 ELISA Kit is a Sandwich (quantitative) ELISA for the measurement of Human Cystatin SA\/CST2 2 in Human in Biofluids, Cell Culture Media samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nDetection method:Colorimetric,\u003cbr\u003e\nSample types:Serum, Plasma, Cell culture supernatant,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nAssay type:Sandwich (quantitative),\u003cbr\u003e\nSensitivity:= 0.38 ng\/mL,\u003cbr\u003e\nRange:0.38 - 100 ng\/mL,\u003cbr\u003e\nAssay Platform:Pre-coated microplate (12 x 8 well strips)\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHuman Cystatin SA\/CST2 2 ELISA kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Cystatin SA\/CST2 2 in serum (human Cystatin SA\/CST2 2 concentration is low in normal serum\/plasma, and may not be detectable in this assay), plasma and cell culture supernatants. This assay employs an antibody specific for human Cystatin SA coated on a 96-well plate.\u003cbr\u003e\nThis ELISA kit shows no cross-reactivity with the following cytokines tested: human ADAMTSL-1\/Punctin-1, AMSH\/STAMBP, Annexin V, BATF3, Bora, Cadherin-17, Caveolin-2, CD2, CD200 R1, CHST3, COMT, Dopamine beta-Hydroxylase, Desmin,Exostosin-like 3, Ficolin-1, FosB\/GOS3, FRS2, GATA-5, GFAP, GLI-3, HepaCAM, ARNT\/HIF-1 beta, 17 betaHSD1\/HSD17B1, IDO, Kallikrein 1, Kell, MDL-1\/CLEC5A, NPDC-1, Numb, Olig2, p63\/TP73L, Pax3, Semaphorin 4D, Sphingosine Kinase 1\/SPHK1, TAZ\/WWTR1, TC-PTP, Transglutaminase 3\/TGM3, TPST2, TREML1\/TLT-1.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCystatin SA also known as CST2 is a member of the cystatin superfamily which are cysteine protease inhibitors. It has a molecular mass of approximately 16 kilodaltons. This protein is expressed mainly in the human saliva and tears where it helps to protect the oral cavity and ocular surface by inhibiting protease activity. The primary role of Cystatin SA is to bind tightly to its target cysteine proteases preventing them from degrading proteins in these sensitive tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCystatin SA plays an important role in maintaining tissue integrity and homeostasis. It is not known to be part of a complex but operates individually to inhibit cysteine proteases like cathepsin B H and L. By controlling the proteolytic activities of these enzymes Cystatin SA helps to prevent excessive tissue breakdown and inflammation which contributes to the preservation of mucosal barriers in the body.\u003cbr\u003e\nPathways\u003cbr\u003e\nCystatin SA's inhibitory action plays a significant role in proteolysis and inflammation pathways. One important pathway involves cathepsins which are targeted by Cystatin SA to modulate their activity. Another related pathway includes tissue remodeling where Cystatin SA helps regulate protease activities to maintain structural balance. Both these pathways emphasize its interaction with similar cystatins such as Cystatin C in modulating protease activities to protect tissues.\u003cbr\u003e\nCystatin SA has been implicated in conditions such as periodontitis and dry eye syndrome. In periodontitis altered Cystatin SA levels can affect the proteolytic balance contributing to tissue destruction and inflammation. For dry eye syndrome its role in protecting ocular surfaces brings it into focus as a protective factor. Changes in Cystatin SA expression are often correlated with such conditions and it connects with other proteins like cathepsin L which is involved in tissue damage in these disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843771257001,"sku":"ab314724","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab314724","provider":"Iright","version":"1.0","type":"link"}