{"product_id":"abcam-ab315079","title":"Abcam, ab315079, Recombinant Human PTN\/Pleiotrophin Protein","description":"\u003cp\u003eSize: 10µg \/ 50µg \/ 100µg\u003cbr\u003e\nRecombinant Human PTN\/Pleiotrophin Protein is a Human Full Length protein, in the 33 to 168 aa range, expressed in HEK 293 cells, with \u0026gt;95%, \u0026lt;0.005 EU\/µg endotoxin level, suitable for Mass Spec, HPLC.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;95% HPLC,\u003cbr\u003e\nEndotoxin level:\u0026lt;0.005 EU\/µg,\u003cbr\u003e\nExpression system:HEK 293 cells,\u003cbr\u003e\nTags:Tag free,\u003cbr\u003e\nApplications:HPLC, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nMass Spectrometry:LC-MS\/MS,\u003cbr\u003e\nAccession:P21246,\u003cbr\u003e\nAnimal free:Yes,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.4Constituents: 10.26% Trehalose, 0.727% Dibasic monohydrogen potassium phosphate, 0.428% Potassium phosphate monobasic\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions-Ambient, Appropriate long-term storage conditions-Ambient\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPleiotrophin also known as PTN Ptn or $Ptn is a heparin-binding growth factor with a molecular mass of approximately 18 kDa. It is expressed in various tissues notably in the brain during embryonic development and also in adulthood. PTN plays a fundamental role in cellular proliferation differentiation and survival. As a secreted protein it interacts with cell surface receptors to trigger intracellular signaling pathways.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPleiotrophin functions as a potent mitogen promoting cell growth and angiogenesis. It does not operate as part of a larger protein complex but acts independently to influence cellular behavior. Its interaction with receptor protein tyrosine phosphatase (RPTP) modulates the tyrosine phosphorylation state of other proteins affecting downstream signaling. This interaction facilitates communication between cells and their environments influencing development and tissue maintenance.\u003cbr\u003e\nPathways\u003cbr\u003e\nThis protein significantly impacts the PI3K\/Akt and MAPK\/ERK pathways key regulators of cell survival and proliferation. PTN often collaborates with proteins like Midkine (MK) due to their functional similarities and overlapping receptor targets. These pathways help regulate cellular responses to environmental cues contributing to processes such as tissue repair and regeneration.\u003cbr\u003e\nThe overexpression of pleiotrophin has been linked to the development of cancers such as breast cancer and glioblastoma. PTN's interaction with oncogenic pathways often involving proteins like N-cadherin enhances its relevance in tumor progression and metastasis. Additionally alterations in PTN expression or activity can influence neural disorders highlighting its importance in both oncological and neurological contexts.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843957182633,"sku":"ab315079","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab315079","provider":"Iright","version":"1.0","type":"link"}