{"product_id":"abcam-ab315167","title":"Abcam, ab315167, Anti-INTS11 antibody [EPR28317-52-] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal INTS11 antibody. Carrier free. Suitable for WB, IP and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28317-52,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab315167 is the carrier-free version of\u003cbr\u003e\nab315166\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nINTS11 also known as Integrator Complex Subunit 11 is an important component of the integrator complex involved in transcriptional regulation. It weighs approximately 52 kDa. INTS11 shows expression in various tissues with higher levels in testis brain and skeletal muscle. It acts as a subunit of the Integrator complex playing a role in the processing of small nuclear RNA (snRNA).\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe integrator complex containing INTS11 associates with the C-terminal domain of RNA polymerase II. This connection suggests its role in RNA processing events. INTS11 in collaboration with other subunits like INTS9 contributes to the cleavage and 3'-end processing of nascent snRNAs. The accurate processing of snRNA is essential for proper spliceosome formation and function impacting overall RNA maturation.\u003cbr\u003e\nPathways\u003cbr\u003e\nINTS11 participates in RNA splicing and processing related pathways including the major spliceosomal pathway. It forms a vital axis with INTS9 another integrator complex subunit to assist in proper RNA transcription termination and processing. Its activity intersects with RNA polymerase II emphasizing its influence on RNA biosynthesis and turnover.\u003cbr\u003e\nMutations and dysregulation in INTS11 have been linked to neurological disorders and certain cancers. Disruption in its expression or function can lead to faulty RNA processing and splicing highlighting its impact on cellular homeostasis. Additionally INTS11 shows interaction with proteins like cyclin-dependent kinase CDK8 suggesting its regulatory effects on cell cycle and transcriptional control.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851928129705,"sku":"ab315167","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab315167","provider":"Iright","version":"1.0","type":"link"}