{"product_id":"abcam-ab316003","title":"Abcam, ab316003, Anti-AP4B1 antibody [EPR28048-85] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal AP4B1 antibody. Carrier free. Suitable for WB and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28048-85,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab316003 is the carrier-free version of\u003cbr\u003e\nab316002\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nAP4B1 also known as Adaptor-Related Protein Complex 4 Beta 1 Subunit plays a critical role in the cellular transport mechanism. It is a component of the AP-4 adaptor complex which is involved in the sorting of cargo proteins at the trans-Golgi network. The protein has a mass of approximately 82 kDa. AP4B1 is primarily expressed in the brain and other tissues indicating its essential role in neuronal function and development.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAP4B1 contributes to the function of the adaptor protein complex 4 (AP-4). This complex is important for recognizing and binding to sorting signals within the cytoplasmic tails of membrane proteins. AP4B1 facilitates the proper trafficking of proteins to endosomes and lysosomes impacting cellular homeostasis and function. Failure in such trafficking processes often leads to cellular malfunction.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe AP4B1 protein is integral to pathways involving vesicular transport and protein sorting. It interacts with other adaptor-related proteins like AP4M1 within the AP-4 complex influencing the export of proteins from the Golgi apparatus. Additionally AP4B1 affects the lysosomal delivery of proteins playing a role in clathrin-independent pathways essential for maintaining cellular stability.\u003cbr\u003e\nAP4B1 mutations are associated with neurologic conditions such as spastic paraplegia type 47 (SPG47). These mutations lead to improper sorting and trafficking of proteins contributing to neurodegeneration. Furthermore AP4B1 interactions with other proteins in the AP-4 complex like AP4E1 can exacerbate these conditions highlighting the importance of the complex in maintaining neurological health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852545216681,"sku":"ab316003","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab316003","provider":"Iright","version":"1.0","type":"link"}