{"product_id":"abcam-ab316111","title":"Abcam, ab316111, Anti-SPG3A\/ATL1 antibody [EPR28057-64]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SPG3A\/ATL1 antibody. Suitable for WB, IHC-P, ICC\/IF, IHC-Fr, Flow Cyt (Intra), IP and reacts with Transfected cell lysate - Human, Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28057-64,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, IP, IHC-Fr, Flow Cyt (Intra), IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSPG3A also known as Atlastin-1 or ATL1 is a GTPase enzyme with a molecular mass of approximately 64 kDa. This protein is highly important in the mechanical process of membrane trafficking and the maintenance of the endoplasmic reticulum (ER) network. Atlastin-1 is expressed predominantly in neurons especially in the cerebral cortex and the hippocampus where it plays a role in neural function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nAtlastin-1 is involved in the fusion of ER membranes contributing to the network's tubular structure. The protein facilitates the dimerization and fusion of ER membranes a function that is fundamental for creating a continuous and smooth ER network. While it does not form part of a large protein complex its role in membrane dynamics involves interaction with other proteins that maintain ER structure and function.\u003cbr\u003e\nPathways\u003cbr\u003e\nAtlastin-1 participates in the ER and Golgi-related pathways essential for protein trafficking and cellular homeostasis. It has significant interactions in these pathways with proteins like REEP1 and spastin both of which assist in maintaining the dynamic structure of the ER. These interactions underline Atlastin-1's contribution to vesicle transport and membrane fusion processes.\u003cbr\u003e\nMutations in the Atlastin-1 gene can lead to hereditary spastic paraplegia (HSP) a group of inherited disorders characterized by weakness and stiffness of the legs. This protein interacts in the context of HSP with proteins like spastin both of which are implicated in similar neuronal membrane dynamics disorders. Another condition linked to Atlastin-1 dysregulation is neuropathy where the protein's failure to maintain ER integrity can contribute to neuronal degradation.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850255552681,"sku":"ab316111","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab316111","provider":"Iright","version":"1.0","type":"link"}