{"product_id":"abcam-ab317608","title":"Abcam, ab317608, Anti-SHANK1 + SHANK2 + SHANK3 antibody [EPR26549-87]","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal SHANK2 antibody. Suitable for WB, IHC-Fr, Flow Cyt (Intra), IHC-P and reacts with Recombinant fragment - Human, Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR26549-87,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Rat, Human,\u003cbr\u003e\nApplications:Flow Cyt (Intra), WB, IHC-Fr, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:Unsuitable for rat IHC-Fr and human IHC-P.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSHANK1 SHANK2 and SHANK3 also known as proline-rich synapse-associated protein 1 2 and 3 serve important mechanical roles as scaffolding proteins at the postsynaptic density of excitatory synapses in the brain. SHANK proteins range between approximately 170-220 kDa in mass. They are expressed widely in the brain particularly in regions such as the cerebral cortex and the hippocampus important for higher brain functions. These proteins interact directly with multiple synaptic proteins to maintain synaptic architecture and signal transduction.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nSHANK proteins are integral to the formation and function of synaptic assemblies. They are components of a complex called the postsynaptic density where they link neurotransmitter receptors with cytoskeletal elements. These proteins play an important role in organizing the synaptic machinery necessary for neurotransmission. By anchoring various receptors and proteins at synapses SHANK proteins influence synaptic strength and plasticity essential for learning and memory.\u003cbr\u003e\nPathways\u003cbr\u003e\nSHANK proteins are critical in the N-methyl-D-aspartate receptor (NMDAR) and metabotropic glutamate receptor (mGluR) signaling pathways. SHANK proteins associate with proteins like Homer and GKAP which modulate these pathways. By interacting with these partners SHANK proteins contribute to the regulation of excitatory synaptic transmission and are involved in mechanisms of synaptic plasticity such as long-term potentiation.\u003cbr\u003e\nSHANK proteins are implicated in several neurodevelopmental disorders including autism spectrum disorders (ASD) and schizophrenia. Mutations in SHANK3 in particular have strong associations with ASD. In these disorders altered SHANK function disorganizes synaptic assemblies and signaling leading to neural circuitry dysfunction. In autism dysregulation of SHANK proteins impacts NMDA receptor function which connects also to interaction with proteins like NRXN and GRIN2A contributing to the symptoms associated with these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848550437033,"sku":"ab317608","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab317608","provider":"Iright","version":"1.0","type":"link"}