{"product_id":"abcam-ab318133","title":"Abcam, ab318133, Anti-XRN2 antibody [EPR28598-13] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal XRN2 antibody. Carrier free. Suitable for IHC-P, WB, Flow Cyt (Intra), ICC\/IF and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28598-13,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:WB, ICC\/IF, Flow Cyt (Intra), IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab318133 is the carrier-free version of\u003cbr\u003e\nab318132\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nXRN2 also known as 5'-3' exoribonuclease 2 is an enzyme involved in RNA metabolism. It has a molecular mass of approximately 105 kDa. XRN2 scavenges for the degradation of uncapped nascent RNA by cleaving RNA in the 5' to 3' direction after exonucleolytic cleavage. Predominantly expressed in the nucleus XRN2 plays an important role in RNA turnover and processing contributing to the precise control of gene expression within eukaryotic cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\n5'-3' exoribonuclease 2 regulates the termination of transcription facilitating the completion of the RNA synthesis process. XRN2 functions in coordination with other components within transcription termination complexes such as the exosome. These complexes ensure the removal of excess or faulty RNA which is critical for maintaining cellular homeostasis. XRN2's activity aids in silencing transcriptional noise and preventing the accumulation of defective RNA species.\u003cbr\u003e\nPathways\u003cbr\u003e\n5'-3' RNA decay and termination are where XRN2 finds its primary function. It is a part of the exosome-mediated RNA decay pathway and contributes to effective gene expression pathways. In these pathways XRN2 functions alongside proteins such as Rrp6 and other cofactors ensuring the fidelity of RNA processing is maintained. It interacts with proteins involved in RNA polymerase II-mediated transcriptional processes highlighting its integral role in gene expression regulation.\u003cbr\u003e\nImproper function or expression of XRN2 is linked to cancer and neurodegenerative diseases. In cancer alterations in RNA processing pathways involving XRN2 can lead to unchecked cellular proliferation. Additionally proteins like SEPT7 are sometimes altered in these pathways contributing to oncogenic potentials. In neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) disrupted XRN2 function can result in abnormal RNA processing and neuronal damage. Here interactions with proteins like TDP-43 can exacerbate disease pathology linking XRN2 to complex disease mechanisms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851879796905,"sku":"ab318133","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab318133","provider":"Iright","version":"1.0","type":"link"}