{"product_id":"abcam-ab318198","title":"Abcam, ab318198, Anti-Myocilin antibody [EPR28799-15] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nRabbit Recombinant Monoclonal Myocilin antibody. Carrier free. Suitable for WB, ICC\/IF, Flow Cyt (Intra) and reacts with Human, Mouse, Rat samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR28799-15,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:ICC\/IF, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab318198 is the carrier-free version of\u003cbr\u003e\nab318197\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMyocilin also known as Trabecular Meshwork Inducible Glucocorticoid Response protein (TIGR) is a protein mainly involved in ocular processes. It weighs about 55 kDa and contains several key domains including a leucine zipper motif and an olfactomedin-like domain. Myocilin is abundantly expressed in the trabecular meshwork of the eye skeletal muscle heart and brain. The protein appears in both intracellular and secreted forms and undergoes glycosylation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein plays an important role in the regulation of intraocular pressure by influencing the outflow of aqueous humor through the trabecular meshwork. It is also known to be part of a protein complex that interacts with other extracellular matrix components to maintain the structural integrity of tissues. Beyond the eye Myocilin similarly contributes to cellular processes in other tissues assisting in maintaining cellular structure and integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nMyocilin functions within the Wnt signaling pathway and extracellular matrix-receptor interaction pathway. These pathways are significant in regulating cell growth adhesion and differentiation in various tissues. In the Wnt signaling pathway Myocilin interacts with proteins such as Frizzled receptors affecting the downstream effects on cell behavior and fate. In the extracellular matrix pathway Myocilin associates with collagens and laminins influencing tissue architecture and dynamics.\u003cbr\u003e\nMyocilin plays a significant role in glaucoma and Myocilin-related ocular hypertension. Glaucoma often involves elevated intraocular pressure due to impaired aqueous humor outflow in which mutated Myocilin may not function properly affecting cellular interactions and contributing to disease progression. Links have been identified with proteins like optineurin in the context of glaucoma where these proteins can collectively influence disease pathophysiology and lead to optic nerve damage if dysregulated.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46851570630825,"sku":"ab318198","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab318198","provider":"Iright","version":"1.0","type":"link"}