{"product_id":"abcam-ab318989","title":"Abcam, ab318989, Anti-influenza A H1N1 (A\/California\/07\/2009) neuraminidase antibody [CD6] - BSA and Azide free","description":"\u003cp\u003eSize: 100µg \/ 1mg\u003cbr\u003e\nMouse Recombinant Monoclonal N1, influenza H1N1, A\/California\/07\/2009 antibody. Carrier free. Suitable for ICC\/IF, I-ELISA and reacts with Transfected cell line - Influenza A virus (A\/California\/07\/2009(H1N1)), Recombinant full length protein - Influenza A virus (A\/California\/07\/2009(H1N1)) samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:CD6,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Influenza A virus (A\/California\/07\/2009(H1N1)),\u003cbr\u003e\nApplications:I-ELISA, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.,\u003cbr\u003e\nSpecificity:This antibody reacts with Influenza A virus H1N1, A\/California\/07\/2009 neuraminidase and does not react with Influenza A virus H1N1, A\/Brisbane\/59\/2007 neuraminidase or Influenza A virus H7N9, A\/Anhui\/1\/2013 neuraminidase.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab318989 is the carrirer-free version of\u003cbr\u003e\nab318988\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003cbr\u003e\nWant a custom formulation?\u003cbr\u003e\nThis antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com\u003cbr\u003e\nConjugation ready\u003cbr\u003e\nOur carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.\u003cbr\u003e\nUse our\u003cbr\u003e\nconjugation kits\u003cbr\u003e\nfor antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.\u003cbr\u003e\nCompatibility\u003cbr\u003e\nThis product is compatible with the Maxpar\u003cbr\u003e\nAntibody Labeling Kit from Fluidigm, without the need for antibody preparation. Maxpar\u003cbr\u003e\nis a trademark of Fluidigm Canada Inc.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nInfluenza A H1N1 (A\/California\/07\/2009) neuraminidase also known as NA is an enzyme important for the viral life cycle. It cleaves sialic acid groups from glycoproteins facilitating the release of new virus particles from host cells. This process aids the spread of infection within the host. Neuraminidase of H1N1 has a molecular mass of around 60 kDa. It is expressed on the surface of the influenza virus where it functions to support the viral budding process.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nNeuraminidase enables the influenza virus to exit infected cells and invade new ones ensuring efficient viral dissemination. It functions as part of a complex with the viral hemagglutinin protein which helps the virus attach to the host cell surface before infection. Neuraminidase's enzymatic action counteracts hemagglutinin's binding by cutting sialic acid residues from host receptors an essential function for viral replication.\u003cbr\u003e\nPathways\u003cbr\u003e\nNeuraminidase plays a role in the influenza viral budding and release pathway coordinating with hemagglutinin to manage the balance between virus attachment and release. This action relates to various antiviral research efforts aimed at blocking this process focusing on the hemagglutinin-neuraminidase balance. Interventions at this level may inhibit the virus' ability to proliferate highlighting the importance of neuraminidase in therapeutic pathways targeting influenza.\u003cbr\u003e\nNeuraminidase is directly linked to influenza infection a respiratory illness with pandemic potential. Inhibitors like oseltamivir and zanamivir are designed to block neuraminidase activity preventing the virus' spread in the body. These inhibitors target the interaction between neuraminidase and sialic acid residues aiming to disrupt the pathogenesis of the influenza virus. This interaction offers a promising target for therapeutic strategies against influenza virus strains including potential drug-resistant variants.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855383187625,"sku":"ab318989","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab318989","provider":"Iright","version":"1.0","type":"link"}