{"product_id":"abcam-ab321948","title":"Abcam, ab321948, BOND RX - Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal","description":"\u003cp\u003eSize: 1Kit\u003cbr\u003e\nRabbit Recombinant Monoclonal PDGFR alpha + PDGFR beta antibody. Suitable for detection of PDGFR alpha + PDGFR beta in IHC. Suitable for Human, Mouse, Rat samples. This product is a bundle of 2 x BOND Titration Containers (with 6mL inserts) along with 100 uL vial of Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal - ab32570. - Validated on the Leica BOND RX automated IHC staining platform for PDGFR alpha + PDGFR beta IHC - Specificity confirmed with PDGFRB knockout cell line validation - Y92 clone cited in over 330 publications - Using biophysical QC, antibody identity is confirmed at a molecular level for unrivaled batch-batch consistency\u003cbr\u003e\nProduct details:\u003cbr\u003e\nThis product is a bundle of 2 x BOND Titration Containers (with 6mL inserts) along with 100 uL vial of Anti-PDGFR alpha + PDGFR beta antibody [Y92] - C-terminal -\u003cbr\u003e\nab32570\u003cbr\u003e\nAdditional Titration Inserts can be purchased from Leica Biosystems, using OPT9719 (box of 50). Or Titration Container\/Insert Kit, using OPT9049 (box of 10\/50).\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information--20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPDGFR alpha also known as platelet-derived growth factor receptor alpha is a cell surface receptor tyrosine kinase with a mass of approximately 123 kDa. It plays a mechanical role in transmitting signals across the cell membrane initiating cellular responses. PDGFR alpha is widely expressed in mesenchymal cells including fibroblasts and smooth muscle cells. Researchers frequently employ techniques such as PDGFRA IHC and PDGFRA staining to study the localization and expression levels in tissues.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPDGFR alpha mediates cell proliferation survival and differentiation especially in embryonic development and wound healing. The receptor often forms a complex by dimerizing with itself or with PDGFR beta to activate intracellular signaling cascades. This process is initiated upon ligand binding which triggers autophosphorylation on tyrosine residues. The receptor is also recognized in the detection of PDGFRA with assays such as PDGFRA ELISA.\u003cbr\u003e\nPathways\u003cbr\u003e\nPDGFR alpha significantly affects the MAPK and PI3K\/AKT signaling pathways which regulate cellular growth and survival signals. Through these pathways PDGFR alpha interacts with related proteins like SHP-2 and PI3K contributing to signal transduction involved in cellular responses. This role links PDGFR alpha to important cellular processes via its kinase activity and signal integration.\u003cbr\u003e\nPDGFR alpha is implicated in conditions such as gastrointestinal stromal tumors (GISTs) and idiopathic pulmonary fibrosis (IPF). It connects to proteins such as KIT in GISTs where mutations cause aberrant receptor signaling leading to tumorigenesis. Aberrant PDGFR alpha signaling also associates with IPF a disorder characterized by increased fibroblast proliferation and fibrotic tissue formation. These connections make PDGFR alpha a significant target for research and therapeutic intervention.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843615117481,"sku":"ab321948","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab321948","provider":"Iright","version":"1.0","type":"link"}