{"product_id":"abcam-ab322087","title":"Abcam, ab322087, Recombinant Human PlGF Protein Standard (His tag)","description":"\u003cp\u003eSize: 10µg\u003cbr\u003e\nRecombinant Human PlGF Protein Standard (His tag) is a Human Fragment protein, expressed in HEK 293 cells, with \u0026gt;80%, suitable for SDS-PAGE, sELISA.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;80% SDS-PAGE,\u003cbr\u003e\nExpression system:HEK 293 cells,\u003cbr\u003e\nTags:His tag C-Terminus,\u003cbr\u003e\nApplications:sELISA, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:No,\u003cbr\u003e\nAccession:P49763,\u003cbr\u003e\nAnimal free:Yes,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.3 - 7.5Constituents: 2.922% Sodium chloride, 0.64107% disodium;hydrogen phosphate;dodecahydrate, 0.02858% Potassium phosphate monobasic\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhile the standard is the same as the one provided in the corresponding SimpleStep ELISA Kit, it cannot be treated as the consumable provided with our SimpleStep ELISA Kit due to differences in its concentration calibration.\u003cbr\u003e\nAbcam guarantee that this protein standard is suitable for use in a sandwich ELISA. Individual results may vary due to differences in technique, laboratory equipment, buffers, and other experimental factors. The detection range provided for this protein standard is based on initial sandwich ELISA validation data.\u003cbr\u003e\nThe protein concentration is the concentration after validation on our sandwich ELISA platform. This Standard protein is guaranteed to work with our Capture and Detector antibodies in sELISA. Please contact our\u003cbr\u003e\nScientific Support\u003cbr\u003e\nteam to know which antibody pair is suitable for this protein.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPlacental Growth Factor also known as PLGF is a member of the vascular endothelial growth factor (VEGF) family. It is a homodimeric glycoprotein with a molecular weight of approximately 29 kDa. PLGF is mainly expressed in the placenta but it is also found in other tissues like the heart lungs and thyroid. Its main role is to bind to the VEGFR-1 receptor leading to angiogenesis and vasculogenesis. These processes involve new blood vessel formation which is important for fetal development and wound healing.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPLGF plays an important role in the modulation of angiogenesis. It does not work alone; it often acts in synergy with VEGF-A to regulate blood vessel growth. PLGF has the ability to promote the proliferation and migration of endothelial cells which are essential components for blood vessel formation. Additionally its expressions adapt depending on physiological conditions like in pregnancy where it supports placental vascular development. Through its actions PLGF influences vascular permeability and contributes to physiological and pathological processes linked to blood vessel formation.\u003cbr\u003e\nPathways\u003cbr\u003e\nPLGF is significant in the VEGF signaling pathway which controls angiogenesis and lymphangiogenesis. It interacts with VEGFR-1 to mediate effects on endothelial cell activity. This interaction is important because VEGFR-1 acts as a decoy receptor modulating VEGF-A signaling. Another important pathway where PLGF is involved is the inflammatory response pathway where it influences monocyte migration and cytokine production acting closely with inflammation-related proteins.\u003cbr\u003e\nPLGF levels associate strongly with preeclampsia a condition in pregnancy marked by hypertension and organ dysfunction. Reduced PLGF levels can indicate preeclampsia as the balance of angiogenic factors gets disrupted affecting placental function. Another disorder linked with PLGF is cancer particularly in tumor angiogenesis where its elevated expression supports the growth and spread of tumors by promoting new blood vessel formation. Changes in PLGF levels can interact with proteins like VEGF-A to influence these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843940470953,"sku":"ab322087","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab322087","provider":"Iright","version":"1.0","type":"link"}