{"product_id":"abcam-ab322770","title":"Abcam, ab322770, Biotin Anti-Complement C8a antibody [EPR23646-33] (Detector)","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Recombinant Monoclonal CO8A antibody - conjugated to Biotin. Suitable for sELISA and reacts with Human samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR23646-33,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nConjugation:Biotin,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nApplications:sELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nHow are conjugated primary antibodies validated?\u003cbr\u003e\nThis conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling.\u003cbr\u003e\nFor suitable applications and species reactivity, please refer to the unconjugated version of this clone.\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 30% Glycerol (glycerin, glycerine), 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle, Store in the dark\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nComplement C8a also known as C8 alpha chain is a part of the complement system which plays a role in immune response. It has a molecular mass of approximately 64 kDa. This protein is found in blood plasma and is mainly expressed in hepatocytes. The C8a forms the terminal subunit of the C8 protein complex which is critical for the formation of the membrane attack complex (MAC) that disrupts the lipid bilayer of target cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe C8a chain works in concert with C8 beta and C8 gamma to form the C8 complex of the complement system. This protein becomes part of the larger MAC a lytic complex that facilitates cell membrane disruptions thereby initiating cell lysis. The membrane attack complex plays a defensive role against pathogenic microorganisms contributing to innate immunity.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe complement system involving C8a plays a central role in the innate immune pathway and the alternative pathway of complement activation. These pathways are essential for the protection against infections. The C5 convertase acts upstream of C8a cleaving C5 to C5b which then associates with C6 and C7 allowing C8a and its counterparts C8b and C8g to bind and initiate MAC formation. C9 is the final protein to bind completing the complex and resulting in the lysis of the target.\u003cbr\u003e\nThe deficiency or dysfunction in C8a can be associated with increased susceptibility to Neisseria infections particularly meningococcal disease. C8 deficiency is often linked with deficiencies in C5-C9 proteins as these proteins are collectively critical for functional MAC formation. Immunological responses depending on the formation of the MAC can become compromised increasing vulnerability to certain bacterial infections.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46848519209129,"sku":"ab322770","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab322770","provider":"Iright","version":"1.0","type":"link"}