{"product_id":"abcam-ab323238","title":"Abcam, ab323238, Anti-Vimentin antibody [EPR3776] - Cytoskeleton Marker – Chicken IgY (Chimeric)","description":"\u003cp\u003eSize: 20µL \/ 100µL \/ 1mL\u003cbr\u003e\nChicken Recombinant Monoclonal Vimentin antibody. Suitable for ICC\/IF, IHC-P and reacts with Human, Mouse samples.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Chicken,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR3776,\u003cbr\u003e\nIsotype:IgY,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse,\u003cbr\u003e\nApplications:IHC-P, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis chicken monoclonal chimeric antibody has been engineered from a RabMAb parent antibody (\u003cbr\u003e\nab92547\u003cbr\u003e\n). By necessity, some rabbit sequence is retained as part of the variable domain. When multiplexing with other rabbit-derived antibodies, using cross absorbed Fc-reactive secondary antibodies are recommended.\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Thiophilic Resin, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPathways\u003cbr\u003e\nVimentin plays a role in the epithelial-to-mesenchymal transition (EMT) and interacts within the TGF-beta signaling pathway. It works alongside proteins like N-cadherin and fibronectin in the EMT pathway contributing to increased cell motility and survival. This involvement positions vimentin as a control point reflecting changes in cell phenotypes under physiological and pathological conditions.\u003cbr\u003e\nVimentin also known by its scientific name VIM is a type of intermediate filament protein that forms part of the cytoskeleton. It has a molecular mass of approximately 57 kDa. Vimentin is expressed in various cell types including mesenchymal cells fibroblasts and endothelial cells. This protein maintains cell integrity and provides resistance against stress by organizing cellular architecture and anchoring organelles. Researchers often use antibodies such as anti-vimentin or anti-mouse vimentin to study its expression and functions in cell biology.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe role of vimentin involves providing structural support and participating in processes like cell division and wound healing. Vimentin forms complexes with other cytoskeletal proteins significantly impacting cell shape and mobility. Its involvement in cellular stability becomes paramount during events requiring cellular reorganization such as embryogenesis and inflammation. These functions are frequently observed using labeled antibodies like Alexa Fluor 568 and Alexa Fluor 647 for fluorescent imaging.\u003cbr\u003e\nVimentin has relevance in cancer metastasis and cardiovascular diseases. Its aberrant expression correlates with tumor progression and metastatic potential by affecting cell movement and invasion. Vimentin also associates with proteins like collagen and integrins in the context of cardiovascular pathologies influencing vascular stiffness and remodelling. By targeting vimentin researchers aim to understand intervention strategies that may mitigate these diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855495155881,"sku":"ab323238","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab323238","provider":"Iright","version":"1.0","type":"link"}