{"product_id":"abcam-ab33451","title":"Abcam, ab33451, Anti-Monocyte + Macrophage antibody [MOMA-2]","description":"\u003cp\u003eSize: 125µg\u003cbr\u003e\nRat Monoclonal Mouse Macrophage antibody. Suitable for Flow Cyt, IHC-FoFr, IHC-P, IHC-Fr and reacts with Mouse samples. Cited in 124 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rat,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:MOMA-2,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse,\u003cbr\u003e\nApplications:IHC-P, Flow Cyt, IHC-FoFr, IHC-FrSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nSpecificity:This antibody recognises an intracellular antigen of mouse macrophages and monocytes. It reacts strongly with macrophages in lymphoid organs in all mouse strains tested. Staining may also be seen on the epithelium of mucosa.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMonocytes and macrophages often referred to as MO or MOMa-2 are types of white blood cells that play essential roles in the immune system. Monocytes which express various mouse monocyte markers develop in the bone marrow and circulate in the bloodstream. They typically measure about 12 to 15 micrometers in diameter. Monocytes migrate to tissues where they differentiate into macrophages. These macrophages are larger typically 20 micrometers and reside in tissues throughout the body. Macrophages are characterized by their large irregular shape and possess a great ability to engulf pathogens and debris.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMonocytes and macrophages help protect the body from infection and clear injured tissue. They operate as part of the innate immune response and also contribute to the adaptive immune response. Macrophages in particular are known for their phagocytic activity where they engulf and digest microorganisms cellular debris and other particles. They secrete cytokines and chemokines that recruit other immune cells to sites of infection or injury. Monocyte to macrophage differentiation allows for the transformation from a circulating cell to a tissue-resident cell adapting to specific tissue functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nMonocytes and macrophages are integral to the inflammatory and immune response pathways. These cells are involved in the Toll-like receptor (TLR) signaling pathway which detects pathogens and initiates immune defense mechanisms. They also participate in the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway regulating cytokine production and cell survival. Macrophages interact with a wide range of proteins including tumor necrosis factor-alpha (TNF-α) which plays an essential role in inflammation and apoptosis.\u003cbr\u003e\nMonocytes and macrophages are linked to chronic inflammatory diseases and infections. Their dysfunction or overactivation has been observed in disorders like atherosclerosis and rheumatoid arthritis. In atherosclerosis macrophages accumulate lipids becoming foam cells and contributing to plaque development with an interaction seen with low density lipoprotein (LDL). In rheumatoid arthritis macrophages release pro-inflammatory cytokines exacerbating joint inflammation and damage often relating to the presence of interleukin-1 (IL-1).\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855739146409,"sku":"ab33451","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab33451","provider":"Iright","version":"1.0","type":"link"}