{"product_id":"abcam-ab34898","title":"Abcam, ab34898, Anti-iASPP antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal IASPP antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 17 publications. Immunogen corresponding to Synthetic Peptide within Human PPP1R13L aa 750-800.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human PPP1R13L aa 750-800. The exact immunogen used to generate this antibody is proprietary information.Q8WUF5,\u003cbr\u003e\nSpecificity:A BLAST analysis was used to suggest cross reactivity with iASPP proteins from human, dog and mouse sources. Expect reactivity against both isoform 1 and isoform 2. Partial reactivity may occur against iASPP from bovine. Reactivity against homologues from other sources is not known.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-This affinity-purified antibody is directed against the human iASPP protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification., Storage buffer-pH: 7.2Preservative: 0.01% Sodium azideConstituents: 0.88% Sodium chloride, 0.424% Potassium phosphate solution, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIASPP also known as inhibitor of apoptosis-stimulating protein of p53 is a regulatory protein with a mass of approximately 96 kDa. It plays an important role in modulating apoptosis functioning as a negative regulator of p53 a well-known tumor suppressor protein. iASPP binds directly to p53 preventing its ability to transactivate target genes associated with cell cycle arrest and apoptosis. This protein is widely expressed in various tissues suggesting its importance in cellular homeostasis and response to stress.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nIASPP negatively affects p53-mediated apoptosis and cellular senescence. It is part of a complex with PP1 acting as a regulatory subunit that influences several cellular processes by modulating dephosphorylation activities. iASPP's interaction with PP1 further impacts gene expression by affecting the phosphorylation status of various transcription factors. This regulatory mechanism suggests iASPP plays a role in controlling cell growth and death essential processes for maintaining normal cellular function.\u003cbr\u003e\nPathways\u003cbr\u003e\nIASPP modulates the p53 pathway an essential mechanism for regulating cell cycle and apoptosis. Within this pathway it associates with proteins like ASPP1 ASPP2 and other family members which also influence p53 activity. iASPP has a role in the NF-kB pathway where it influences inflammation and immune responses. Through these pathways iASPP coordinates signals that determine cellular fate connecting it to fundamental processes in cell biology.\u003cbr\u003e\nIASPP alterations associate with cancer development and progression. Its overexpression often correlates with enhanced tumor growth due to impaired p53 activity. Studies link iASPP to diseases like acute myeloid leukemia (AML) and prostate cancer. Through its interaction with p53 and proteins such as ASPP1 and ASPP2 iASPP provides a potential therapeutic target where modulating its activity might restore proper cellular responses to stress counteracting tumor development.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46845039214761,"sku":"ab34898","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab34898","provider":"Iright","version":"1.0","type":"link"}