{"product_id":"abcam-ab4066","title":"Abcam, ab4066, Anti-S100 antibody [4C4.9]","description":"\u003cp\u003eSize: 500µL\u003cbr\u003e\nAnti-S100 antibody [4C4.9] (ab4066) is a mouse monoclonal antibody detecting S100 in  IHC-P . Suitable for  Human . - Over 80 publications - Trusted since 2003\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:4C4.9,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Full Length Protein corresponding to Cow Protein S100-A1. The exact immunogen used to generate this antibody is proprietary information.P02639\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThis product was changed from ascites to tissue culture supernatant on 29\/01\/2021. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.\u003cbr\u003e\nProduct Specifications\u003cbr\u003e\nAnti-S100 antibody [4C4.9] (ab4066) is a mouse monoclonal antibody and is validated for use in IHC-P in human samples.\u003cbr\u003e\nAnti-S100 antibody [4C4.9] (ab4066) specifically detects S100 (UniProt ID: P23297; Molecular weight: 11kDa) and is sold in 500 µL selling sizes.\u003cbr\u003e\nQuality and Validation\u003cbr\u003e\nAbcam's high quality validation processes ensure Anti-S100 antibody [4C4.9] (ab4066) has high sensitivity and specificity.\u003cbr\u003e\nAnti-S100 antibody [4C4.9] (ab4066) has been cited over 87 times in peer reviewed journals and is trusted by the scientific community.\u003cbr\u003e\nAnti-S100 antibody [4C4.9] (ab4066) has 11 independent reviews from customers.\u003cbr\u003e\nRelated Products\u003cbr\u003e\nConjugation-ready, carrier free format available for antibody clone 4C4.9 -\u003cbr\u003e\nab176243\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.3 - 7.5Preservative: 0.05% Sodium azideConstituents: Tissue culture supernatant, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe S100 protein family consists of low-molecular-weight proteins with individual members like S100B and S100A4 each having distinct roles. S100 proteins range typically between 9 to 13 kDa in mass. They are expressed broadly but especially in the central nervous system where glial cells are an important source and in several epithelial tissues including melanocytes. These proteins are noted for their calcium-binding properties facilitated by EF-hand motifs influencing both intracellular and extracellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nS100 proteins drive diverse cellular functions such as regulation of cell cycle differentiation and motility. They often operate as dimers and participate in the formation of protein complexes impacting cellular signaling networks. By binding calcium S100 proteins undergo conformational changes that allow interaction with target proteins modulating processes like cytoskeleton dynamics and neuronal survival.\u003cbr\u003e\nPathways\u003cbr\u003e\nS100 proteins are significant in the regulation of the MAPK\/ERK and NF-kB pathways. These pathways are critical for cell proliferation apoptosis and response to environmental stress. S100B in particular interacts with the receptor for advanced glycation end-products (RAGE) influencing downstream signaling cascades and amplifying the cellular response to inflammatory stimuli.\u003cbr\u003e\nS100 proteins are implicated in the progression of conditions such as melanoma and Alzheimer's disease. In melanoma S100B levels serve as a biomarker reflecting disease progression potentially interacting with p53 to diminish its tumor suppressor function. In Alzheimer's disease S100B overexpression correlates with neuroinflammation and neuronal damage highlighting its association with disease through pathways involving amyloid-beta and tau proteins.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855741309097,"sku":"ab4066","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab4066","provider":"Iright","version":"1.0","type":"link"}