{"product_id":"abcam-ab40857","title":"Abcam, ab40857, Anti-CCL4\/MIP-1 beta + CCL4L1 antibody [EPR494]","description":"\u003cp\u003eSize: 100µL \/ 1mL\u003cbr\u003e\nRabbit Recombinant Monoclonal CCL4\/MIP-1 beta antibody. Suitable for IP, WB, ICC\/IF and reacts with Human, Synthetic peptide - Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:EPR494,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IP, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nPatented technology\u003cbr\u003e\nOur RabMAb\u003cbr\u003e\ntechnology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to\u003cbr\u003e\nRabMAb® patents\u003cbr\u003e\nWhat are the advantages of a recombinant monoclonal antibody?\u003cbr\u003e\nThis product is a recombinant monoclonal antibody, which offers several advantages including:\u003cbr\u003e\n- High batch-to-batch consistency and reproducibility\u003cbr\u003e\n- Improved sensitivity and specificity\u003cbr\u003e\n- Long-term security of supply\u003cbr\u003e\n- Animal-free batch production\u003cbr\u003e\nFor more information, read more on\u003cbr\u003e\nrecombinant antibodies\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.01% Sodium azideConstituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCCL4 also known as MIP-1 beta and CCL4L1 are chemokines involved in immune responses. These proteins weigh approximately 7.8 kDa. CCL4 and CCL4L1 are expressed in various tissues including lymphoid organs activated T cells and macrophages. Their expression occurs in response to inflammatory signals contributing to the attraction and activation of specific immune cells.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe chemokines CCL4 and its homolog CCL4L1 play important roles in immune cell trafficking and coordination of the inflammatory response. They are involved in recruiting monocytes natural killer cells and various types of T cells to sites of inflammation. CCL4 and CCL4L1 function as part of a larger chemokine system interacting with receptors such as CCR5 to modulate immune responses effectively.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe chemokines CCL4 and CCL4L1 feature prominently in the immune signaling pathway and the MAPK pathway. These pathways regulate immune responses and cell survival. Their interaction with receptor CCR5 links them to other chemokines like CCL3 which also utilizes CCR5. This signaling cascade influences cellular responses essential for proper immune system functioning.\u003cbr\u003e\nCCL4 and CCL4L1 play roles in HIV infection and rheumatoid arthritis. They affect HIV progression by binding to the CCR5 receptor which the virus uses to enter host cells. In rheumatoid arthritis they contribute to synovial inflammation through recruitment of inflammatory cells. These interactions highlight their connection with other proteins like HIV-1 gp120 and CCR5 in HIV and TNF-alpha in rheumatoid arthritis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850231369897,"sku":"ab40857","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab40857","provider":"Iright","version":"1.0","type":"link"}