{"product_id":"abcam-ab422","title":"Abcam, ab422, Anti-Isopeptide antibody [81D1C2]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal Isopeptide antibody. Suitable for WB and reacts with Chemical samples. Cited in 11 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:81D1C2,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nSpecificity:This antibody reacts with the isopeptide : epsilon-(gamma-glutamyl) lysine. There is no cross reaction with either lysine or glutamine. They are specific to the epsilon-(gamma-glutamyl) lysine bond formed by transglutaminase activity.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe ability of this antibody to fix complement is unknown. The isopeptide may be purchased from Bachem Catalog number G-1970.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Constituents: 2% Sucrose, 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nIsopeptide plays an important role mechanically in the formation of stable covalent bonds between proteins. It often refers to the linkage created by the isopeptide bond a type of amide bond that connects the side chain of an amino acid to another chain. These bonds are also significant in protein crosslinking processes. Isopeptide bonds are found in various structural proteins and ubiquitin-like proteins. The target is normally expressed in tissues with high protein turnover and structural maintenance functions.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe functions of isopeptide bonds are central to maintaining protein structure and function. Isopeptide bonds are key in multimeric protein complexes such as those involving ubiquitin and SUMO. These complexes help in post-translational modification processes that regulate protein degradation DNA repair and signal transduction. This ability to form stable linker bonds influences cell cycle and immune responses.\u003cbr\u003e\nPathways\u003cbr\u003e\nThese bonds partake in pathways related to protein homeostasis and cell signaling. Isopeptide bonds are essential in the ubiquitin-proteasome pathway facilitating the tagging of proteins for degradation. Related proteins such as ubiquitin and E3 ligases are involved in these pathways. Isopeptide bonds also participate in the signal transduction pathways by modifying signaling proteins through ubiquitination.\u003cbr\u003e\nIsopeptide bonds have been linked to neurodegenerative diseases and certain types of cancers. Aberrations in the ubiquitin-proteasome pathway can lead to the accumulation of misfolded proteins contributing to conditions like Parkinson's disease. Proteins such as ubiquitin and E3 ligases have connections in these disorders. Moreover dysregulation of protein complex formation via isopeptide bonds can result in tumorigenesis due to disrupted cell cycle control.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854628212905,"sku":"ab422","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab422","provider":"Iright","version":"1.0","type":"link"}