{"product_id":"abcam-ab45073","title":"Abcam, ab45073, Anti-ESAT6 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal ESAT6 antibody. Suitable for WB and reacts with Mycobacterium tuberculosis, Mycobacterium bovis samples. Cited in 5 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mycobacterium tuberculosis, Mycobacterium bovis,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nSpecificity:The rabbit polyclonal antibody to EsaT-6 recognizes the EsaT-6 (Rv3875) protein of Mycobacterium tuberculosis and Mycobacterium bovis.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe ESAT-6 protein also known as Early Secretory Antigenic Target 6 kDa is a small highly conserved protein found in Mycobacterium tuberculosis with a molecular mass of approximately 6 kDa. It is secreted by the bacterium and plays a significant role in its pathogenicity. ESAT-6 is expressed strongly during infection particularly within the host macrophages. Its ability to modulate host immune responses makes it an important molecule in tuberculosis research and diagnostics.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nESAT-6 interacts with the host cell's membranes promoting virulence by disrupting immune functions. It does not act alone but forms a complex with the CFP-10 protein which is essential for its stability and secretion. This complex enables ESAT-6 to interfere with immune recognition helping Mycobacterium tuberculosis evade host defenses. These interactions make ESAT-6 a target of protein assays and a focal point in the study of mycobacterium-host interactions.\u003cbr\u003e\nPathways\u003cbr\u003e\nESAT-6 interferes with immune response pathways particularly the path leading to cell-mediated immunity. It directly affects the NF-kB pathway a critical regulator of immune response by destabilizing macrophage lysosomal membranes. The activity of ESAT-6 connects with another protein PhoP involved in regulating virulent gene expression in Mycobacterium tuberculosis. This interaction disrupts normal cellular signaling aiding in bacterial survival within the host.\u003cbr\u003e\nESAT-6 plays a pivotal role in the pathogenesis of tuberculosis a major infectious disease worldwide. The protein's role in attenuating immune responses makes it vital for the persistence of Mycobacterium tuberculosis within the host. Additionally ESAT-6 has connections to other disorders like granuloma formation which results from chronic infections. In tuberculosis the interplay between ESAT-6 and the Rv3879c antigen another virulence factor impacts granuloma development making it a target for therapeutic interventions aimed at combating tuberculosis.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854411223209,"sku":"ab45073","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab45073","provider":"Iright","version":"1.0","type":"link"}