{"product_id":"abcam-ab60847","title":"Abcam, ab60847, Recombinant human PKC epsilon protein","description":"\u003cp\u003eSize: 5µg \/ 10µg\u003cbr\u003e\nRecombinant human PKC epsilon protein is a Human Full Length protein, expressed in Baculovirus infected Sf9 cells, with \u0026gt;90%, suitable for SDS-PAGE, WB, FuncS.\u003cbr\u003e\nKey facts\u003cbr\u003e\nPurity:\u0026gt;90% Densitometry,\u003cbr\u003e\nExpression system:Baculovirus infected Sf9 cells,\u003cbr\u003e\nTags:GST tag N-Terminus,\u003cbr\u003e\nApplications:SDS-PAGE, WB, FuncSSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nBiologically active:Yes,\u003cbr\u003e\nBiological activity:Active,\u003cbr\u003e\nAccession:Q02156,\u003cbr\u003e\nAnimal free:No,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nSpecies:Human,\u003cbr\u003e\nStorage buffer:pH: 7.5Constituents: 25% Glycerol (glycerin, glycerine), 1.74% PMSF, 0.87% Sodium chloride, 0.79% Tris HCl, 0.00385% (R*,R*)-1,4-Dimercaptobutan-2,3-diol, 0.0038% EGTA, 0.00292% EDTA\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nab204875\u003cbr\u003e\n(PKC epsilon peptide) can be utilized as a substrate for assessing kinase activity\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nShipped at conditions-Dry Ice, Appropriate short-term storage conditions--80°C, Appropriate long-term storage conditions--80°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nProtein kinase C epsilon (PKC epsilon) also known as PKCε or epsilon protein is an important serine\/threonine kinase involved in various cellular processes. It has a molecular weight of about 87 kDa. PKC epsilon is widely expressed in different tissues prominently in the brain heart skeletal muscle and endocrine tissues. It belongs to the novel PKC subfamily that responds to diacylglycerol and phospholipids without requiring calcium for activation.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPKC epsilon plays roles in regulating cell survival migration and apoptosis. It is involved in forming signalling complexes with proteins such as receptor for activated C kinase (RACK) and frequently associates with scaffolding proteins. PKC epsilon contributes to the modulation of cytoskeletal reorganization exocytosis and neurotransmitter release impacting cellular communication and function significantly.\u003cbr\u003e\nPathways\u003cbr\u003e\nPKC epsilon is integrated into significant signalling cascades including the MAPK\/ERK and PI3K\/Akt pathways. These pathways influence cell proliferation differentiation and survival. PKC epsilon interacts with proteins like Raf-1 and Akt further modulating signals for cellular responses. Its activity and interactions within these pathways highlight its importance in maintaining cellular homeostasis.\u003cbr\u003e\nPKC epsilon has connections to cancer and cardiovascular diseases. It plays a part in oncogenic processes such as tumorigenesis and metastasis often working alongside proteins like PI3K in these contexts. In cardiovascular conditions PKC epsilon influences cardiac hypertrophy and ischemic heart damage. Its role associating with proteins such as endothelial nitric oxide synthase (eNOS) illustrates its involvement in disease mechanisms where blood flow and myocardial function are affected.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46843830403241,"sku":"ab60847","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab60847","provider":"Iright","version":"1.0","type":"link"}