{"product_id":"abcam-ab61409","title":"Abcam, ab61409, Anti-Prion protein PrP antibody [8H4]","description":"\u003cp\u003eSize: 50µL\u003cbr\u003e\nAnti-Prion protein PrP antibody [8H4] (ab61409) is a mouse monoclonal antibody detecting Prion protein PrP in  Western Blot, Flow Cytometry, IP, IHC-P, ELISA . Suitable for  Cow, Human, Monkey, Mouse, Rat, Sheep . - Over 10 publications - Trusted since 2007\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:8H4,\u003cbr\u003e\nIsotype:IgG2b,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Mouse, Sheep, Monkey, Human, Cow, Rat,\u003cbr\u003e\nApplications:IHC-P, WB, IP, ICC, I-ELISA, Flow CytSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Mouse Prnp.P04925,\u003cbr\u003e\nEpitope:The antibody epitope resides within amino acids 145-180 of human Prion protein PrP.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-Prion protein PrP antibody [8H4] (ab61409) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Flow Cytometry (Flow Cyt), Immunoprecipitation (IP), Immunohistochemistry (IHC-P), ELISA in Cow, Human, Monkey, Mouse, Rat, Sheep samples.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-Prion protein PrP [8H4] (ab61409) was first used in a scientific publication in 2007 and has been cited over 10 times in peer-reviewed journals.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-IgG fraction, Purification notes-Purified Immunoglobulin, Storage buffer-pH: 7.4Preservative: 0.097% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPrion protein also known as PrP or major prion protein plays a mechanical role in the normal functioning of brain cells. It is a glycoprotein with a flexible structure and has an approximate mass of 35-36 kDa. PrP expression is high in nervous tissue. It is present in neurons and glial cells but also surfaces in other tissues like heart and kidney. Alternate names like p-pr-p and f89 refer to specific conformations or studies related to its structure.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPrion protein assists in maintaining normal cell activities. Researchers do not fully understand its exact biological role but it might be involved in copper ion uptake and protection against oxidative stress. PrP can form complexes with other cellular proteins some of which help in routing signals inside the cell. Additionally prion protein may have synaptic functions related to neurodevelopment and neuroprotection.\u003cbr\u003e\nPathways\u003cbr\u003e\nPrion protein links to both neuroprotective and neurodegenerative pathways. It participates in signaling pathways that protect neurons from apoptosis. This protein associates closely with copper-dependent pathways possibly related to its capacity to bind copper ions which affects oxidative stress responses. Prion protein also interacts with proteins like synapsin to modulate synaptic transmission.\u003cbr\u003e\nPrion protein is directly related to prion diseases such as Creutzfeldt-Jakob disease and kuru. These diseases arise from misfolded forms of PrP which aggregate and cause neurodegeneration. The misfolded form referred to as PrP^Sc can induce normal PrP to misfold propagating disease. Dopamine receptor proteins and synaptic proteins can indirectly interact or be affected in these disorders highlighting a complex network of affected neural functions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860544409769,"sku":"ab61409","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab61409","provider":"Iright","version":"1.0","type":"link"}