{"product_id":"abcam-ab64119","title":"Abcam, ab64119, Anti-CAMTA1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal CAMTA1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:The exact immunogen used to generate this antibody is proprietary information.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCAMTA1 also known as calmodulin-binding transcription activator 1 is a transcription factor with a mass of approximately 130 kDa. CAMTA1 plays an important role in gene regulation through its DNA-binding domain. This protein is highly expressed in the brain heart and skeletal muscle indicating its importance in these tissues. CAMTA1 contains a CG-1 DNA-binding domain ankyrin repeats and a calmodulin-binding IQ motif which help in its interaction with different cellular components.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nCAMTA1 regulates the expression of genes involved in the response to environmental stress and the development of neuronal and cardiac tissues. As part of a transcriptional regulatory complex CAMTA1 can recruit other co-factors to modulate gene expression. It influences processes such as neuronal differentiation and cardiac hypertrophy. Its expression pattern and transcriptional activity suggest that it helps maintain cellular homeostasis under varying physiological conditions.\u003cbr\u003e\nPathways\u003cbr\u003e\nCAMTA1 has significant roles in two central biological pathways: calcium signaling and stress response pathways. These pathways are important for neuronal and cardiac function. In calcium signaling CAMTA1 acts alongside other proteins like calmodulin to modulate the expression of genes critical for calcium homeostasis. In stress response pathways it helps regulate genes that protect against cellular stress often collaborating with transcription factors such as MEF2C to mediate stress responses.\u003cbr\u003e\nCAMTA1 is associated with neurodevelopmental disorders and cardiac diseases. Mutations or dysregulation of CAMTA1 expression might contribute to conditions such as ataxia and congenital heart defects. Studies have linked CAMTA1 with other proteins including MEF2C in the context of cardiac development issues suggesting a complex network of interactions essential for normal physiological function.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850156658857,"sku":"ab64119","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab64119","provider":"Iright","version":"1.0","type":"link"}