{"product_id":"abcam-ab6507","title":"Abcam, ab6507, Anti-HSV1 + HSV2 gD antibody [2C10]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nAnti-HSV1 + HSV2 gD antibody [2C10] (ab6507) is a mouse monoclonal antibody detecting HSV1 + HSV2 gD in  Western Blot, ICC\/IF . Suitable for  Herpes simplex virus, Human herpesvirus 2 . - Over 20 publications - Trusted since 2001\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:2C10,\u003cbr\u003e\nIsotype:IgG2a,\u003cbr\u003e\nLight chain type:kappa,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human herpesvirus 2, Herpes simplex virus,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nWhat is this antibody validated in?\u003cbr\u003e\nAnti-HSV1 + HSV2 gD antibody [2C10] (ab6507) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), Immunocytochemistry\/immunofluorescence (ICC\/IF) in Herpes simplex virus, Human herpesvirus 2 samples.\u003cbr\u003e\nTrusted by the scientific community\u003cbr\u003e\nAnti-HSV1 + HSV2 gD [2C10] (ab6507) was first used in a scientific publication in 2001 and has been cited over 20 times in peer-reviewed journals.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nHSV1 and HSV2 glycoprotein D (gD) are envelope proteins found on the surfaces of herpes simplex viruses 1 and 2. The gD protein plays a critical role in the virus life cycle by mediating entry into host cells. It binds with cellular receptors initiating membrane fusion necessary for viral entry. Glycoprotein D is approximately 38 kDa in mass and expresses mainly on the surfaces of infected cells and virion particles. These proteins serve as important targets for immune recognition and are often key in vaccine design strategies.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe gD protein engages with specific cellular receptors like nectin-1 HVEM and others for initiating viral infection. This interaction facilitates the fusion of the viral envelope with the host cell membrane. Glycoprotein D is a part of the larger complex of herpesvirus envelope glycoproteins which work together to enable efficient cell entry and subsequent viral propagation. This coordination within the protein complex ensures the proper attachment and penetration of host cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe gD proteins interact critically within pathways necessary for viral fusion and entry. Their relationship with proteins like glycoproteins B and H\/L within the herpes virus entry mechanism is especially important. Glycoprotein B for example acts after gD-receptor binding to promote the fusion of viral and cell membranes. The fusion and entry pathway dictate the overall success of viral invasion and replication within the host organism.\u003cbr\u003e\nHerpes simplex viruses 1 and 2 associated with the gD protein are most known for causing oral and genital herpes infections. These two forms of infection only require the presence of gD and its interaction with cellular receptors. Additionally gD is linked to herpes-related encephalitis an inflammation of brain tissue caused by the virus. The understanding of gD and its interaction with human cellular proteins offers potential therapeutic and vaccine development pathways potentially helping to manage and control herpes-related health conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46855736459433,"sku":"ab6507","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab6507","provider":"Iright","version":"1.0","type":"link"}