{"product_id":"abcam-ab65163","title":"Abcam, ab65163, Anti-SCN2A antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal SCN2A antibody. Suitable for ICC\/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human SCN2A.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human SCN2A. The exact immunogen used to generate this antibody is proprietary information.Q99250\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Storage buffer-Constituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe SCN2A gene encodes for the Nav1.2 protein a voltage-gated sodium channel alpha subunit with a molecular weight of approximately 260 kDa. This protein acts mechanically by allowing sodium ions to flow into neurons upon depolarization making it fundamental for transmitting electrical signals. Nav1.2 is mainly expressed in the central nervous system especially in the brain regions involved in cognitive functions. Besides Nav1.2 SCI 2A is a popular alternate name for this protein.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe Nav1.2 channel contributes to the generation and propagation of action potentials in neurons. It is part of a larger sodium channel complex that regulates neuronal excitability and synaptic transmission. This channel plays an essential role in maintaining the electrical activity that supports processes like learning and memory. Proper function of Nav1.2 ensures precise neuronal communication which is necessary for normal cognitive and neurological activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe Nav1.2 channel integrates into the action potential pathway where it participates in the initiation and transmission of nerve impulses. It also intersects with synaptic transmission pathways working alongside proteins like Nav1.1 and Nav1.6 to ensure proper synaptic function. These interactions facilitate an effective communication system necessary for maintaining neural network stability.\u003cbr\u003e\nAltered Nav1.2 function associates with epilepsy particularly early-onset epileptic encephalopathies. The gene mutations can disrupt normal sodium channel activity leading to increased neuronal excitability and seizure susceptibility. Furthermore variants in SCN2A link to autism spectrum disorders implicating sodium channel deficiencies in abnormal neurodevelopment. The protein interacts with auxiliary proteins like Navβ1 which influences the severity and presentation of these conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854126010537,"sku":"ab65163","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab65163","provider":"Iright","version":"1.0","type":"link"}