{"product_id":"abcam-ab66968","title":"Abcam, ab66968, Anti-PHF17 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal PHF17 antibody. Carrier free. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human JADE1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human JADE1.Q6IE81\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPHF17 also known as Jade-1 is a protein that plays a significant role in chromatin remodeling and gene transcription. It weighs around 93 kDa and is expressed predominantly in the kidney although it shows presence in other tissues as well. PHF17 functions by recognizing specific histone modifications through its plant homeodomain (PHD) finger domains which enable it to bind to chromatin and influence gene expression.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein is involved in essential cellular processes such as DNA damage response and apoptosis. PHF17 acts as part of larger complexes including its interaction with histone acetyltransferase HBO1 which facilitates the acetylation of histones and impacts chromatin structure. These interactions enable PHF17 to help regulate cell cycle progression contributing to the fine control of cellular proliferation and differentiation.\u003cbr\u003e\nPathways\u003cbr\u003e\nPHF17 holds importance in the DNA damage response pathway and apoptotic pathways. In the DNA damage response it cooperates with proteins like ING4 and ING5 aligning with their roles in chromatin modulation and repair processes. Additionally PHF17's involvement in the apoptotic pathway connects it with p53 a well-known tumor suppressor protein helping mediate cell death under stress conditions or when DNA damage is excessive.\u003cbr\u003e\nPHF17 has a connection to renal cell carcinoma reflecting its high expression in the kidney and its role in apoptosis. It interacts with proteins such as β-catenin suggesting a potential involvement in the Wnt signaling pathway which is often dysregulated in cancers. Furthermore PHF17's participation in DNA repair processes implicates its role in general cancer susceptibility highlighting its importance as a potential therapeutic target.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852261806249,"sku":"ab66968","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab66968","provider":"Iright","version":"1.0","type":"link"}