{"product_id":"abcam-ab67430","title":"Abcam, ab67430, Anti-DIRAS2 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal DIRAS2 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GTP-binding protein Di-Ras2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human GTP-binding protein Di-Ras2.Q96HU8\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nThe DIRAS2 protein also known as Ras homolog gene family member 2 is a small GTPase belonging to the Ras superfamily. This protein has a molecular mass of approximately 21 kDa and shows expression in multiple tissues including the brain heart and skeletal muscles. DIRAS2 plays a role in intracellular signaling modulating signal transduction through its GTP-binding and hydrolyzing capabilities. It interacts with other cellular molecules through its role in Ras superfamily networks affecting various cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThe DIRAS2 protein associates with cellular proliferation and differentiation impacting growth and signaling processes. It is not typically known to be a core component of a larger protein complex but interacts with several effector molecules. These interactions highlight its role in modulating activities that involve growth factors and other signaling elements. DIRAS2's functioning mirrors other small GTPases which regulate important cellular functions.\u003cbr\u003e\nPathways\u003cbr\u003e\nThe DIRAS2 protein engages critically in the MAPK\/ERK signaling pathway contributing to cell growth and differentiation. It also involves in the PI3K\/AKT pathway which influences cell survival and metabolism. In these pathways DIRAS2 relates closely to proteins such as RAF and RAS coordinating signals that lead to cellular adaptive responses. These connections establish pathways where DIRAS2 can modulate signal transmission and cellular outcomes.\u003cbr\u003e\nAlterations in DIRAS2 expression or activity have implications in cancer and neurological disorders. Aberrant DIRAS2 function associates with tumorigenesis given its role in pathways that regulate cell proliferation. In neurology evidence suggests links between DIRAS2 and conditions like schizophrenia due in part to its influence on neuronal signaling pathways. In these contexts associations often include interactions with proteins like AKT in cancer and different synaptic proteins in neurological disorders.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46850139553961,"sku":"ab67430","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab67430","provider":"Iright","version":"1.0","type":"link"}