{"product_id":"abcam-ab68220","title":"Abcam, ab68220, Anti-PDLIM2 antibody","description":"\u003cp\u003eSize: 50µg\u003cbr\u003e\nMouse Polyclonal PDLIM2 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human PDLIM2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:Yes,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human PDLIM2.Q96JY6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nPDLIM2 also known as Mystique or SLIM is a cytoskeletal protein that plays a role in linking actin filaments to various cellular structures. It contains a PDZ domain and a LIM domain which enable it to perform its function within the cell. PDLIM2 has a molecular mass of approximately 36 kDa. It is expressed in several tissue types including immune cells skeletal muscle and epithelial cells indicating its involvement in multiple cellular processes.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nPDLIM2 regulates the stability and activity of certain transcription factors and signaling molecules. It acts as an adapter protein to modulate the interaction of actin filaments with these factors. This protein also influences cell motility and adhesion acting as a critical component of a complex involving the actin cytoskeleton. Its regulation of signal transduction and transcription impacts cellular responses and maintenance of tissue integrity.\u003cbr\u003e\nPathways\u003cbr\u003e\nPDLIM2 plays a central role in the NF-kB signaling pathway and the STAT pathway. By controlling the degradation and transport of nuclear factor NF-kB PDLIM2 affects immune responses and inflammation. Similarly it modulates STAT family proteins involved in pathways that trigger responses to cytokines and growth factors. PDLIM2 interacts with proteins such as RelA and STAT3 indicating its function in cell signaling and gene expression regulation.\u003cbr\u003e\nPDLIM2 links to cancer and autoimmune disorders through its regulatory effects on inflammation and immune responses. Altered expression or function of PDLIM2 can contribute to the progression of certain cancers where it often interacts with oncogenic pathways. Additionally PDLIM2's involvement with proteins like NF-kB and STAT3 associates it with chronic inflammatory and autoimmune diseases further demonstrating its impact on pathological conditions.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46852263575721,"sku":"ab68220","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab68220","provider":"Iright","version":"1.0","type":"link"}