{"product_id":"abcam-ab69992","title":"Abcam, ab69992, Anti-SNPH antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal SNPH antibody. Suitable for WB, IHC-P, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SNPH aa 50-150.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:IHC-P, ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human SNPH aa 50-150. The exact immunogen used to generate this antibody is proprietary information.O15079\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nSNPH also known as Syntaphilin is a protein that acts mechanically by binding to microtubules which is important for its role in anchoring mitochondria within axons. It has a molecular mass of approximately 66 kDa. SNPH predominantly expresses in neurons particularly in the brain suggesting its significant role in the nervous system. This anchoring function helps to regulate energy distribution and calcium buffering within axons highlighting its importance in maintaining proper neuronal function.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis protein modulates mitochondrial distribution by stabilizing microtubules and interacting with the mitochondrial outer membrane. SNPH operates as a part of a complex with motor proteins and microtubular structures which facilitates the stationary positioning of mitochondria along the axons. It helps in energy homeostasis and signal transmission supporting synaptic activity and neuronal health. By influencing mitochondrial dynamics SNPH ensures that neurons maintain energy efficiency and health.\u003cbr\u003e\nPathways\u003cbr\u003e\nSNPH plays a role in cellular processes like the mitochondrial transport and microtubular dynamics pathway. This involves SNPH interacting with proteins such as kinesin and dynein which are motor proteins that move cellular cargo along microtubules. SNPH helps anchor mitochondria by counteracting these transport proteins which helps in the proper positioning of mitochondria needed for neuron function. SNPH's activity is connected to the intracellular energy distribution pathway influencing the energy supply necessary for high-demand areas within the neurons.\u003cbr\u003e\nSNPH is associated with neurodegenerative conditions such as Alzheimer’s disease and Parkinson’s disease. These diseases feature mitochondrial dysfunction and energy imbalances where SNPH’s role in mitochondrial anchoring and distribution becomes disrupted contributing to disease advancement. SNPH’s interactions with amyloid precursor protein in Alzheimer's and alpha-synuclein in Parkinson’s have shown relevance in the pathological processes of these disorders. Understanding SNPH’s function offers insights into therapeutic approaches targeting mitochondrial dynamics in neurodegenerative diseases.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854166347945,"sku":"ab69992","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab69992","provider":"Iright","version":"1.0","type":"link"}