{"product_id":"abcam-ab70215","title":"Abcam, ab70215, Anti-DEFB-4 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal DEFB-4 antibody. Suitable for WB, sELISA, I-ELISA, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human DEFB104A.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:I-ELISA, WB, sELISA, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Recombinant Full Length Protein corresponding to Human DEFB104A.Q8WTQ1\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Lyophilized, Reconstitution-reconstitute with water at 0.5mg\/mL, Purification technique-Affinity purification Immunogen, Storage buffer-Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nDEFB-4 also known as beta-defensin 4 or human beta-defensin 2 (hBD-2) is a small antimicrobial peptide with a mass of about 4.5 kDa. This peptide belongs to the defensin family which plays a role in the immune response. DEFB-4 is expressed in epithelial cells including those in the skin respiratory tract and urogenital tract. It is induced by microbial presence and inflammatory cytokines such as IL-1 and TNF-alpha.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis peptide exhibits antimicrobial activity against bacteria fungi and viruses. DEFB-4 disrupts microbial membranes leading to microbe death. It does not form part of a larger protein complex but it plays an important role in immune defense by recruiting and activating immune cells. It also exhibits chemotactic properties suggesting an involvement in modulating immune responses and interactions with other innate immune system components.\u003cbr\u003e\nPathways\u003cbr\u003e\nDEFB-4 is involved in the innate immune pathway that mediates early responses to infections. Its interaction with the Toll-like receptor (TLR) pathways further enhances cytokine production. DEFB-4 acts alongside other beta-defensins like DEFB-1 contributing to a broader antimicrobial defensive network. Activation of these pathways results in coordinated immune responses that are critical during the early stages of microbial invasion.\u003cbr\u003e\nThe dysregulation of DEFB-4 expression associates with conditions such as psoriasis and cystic fibrosis. In psoriasis increased expression of DEFB-4 correlates with persistent inflammation and immune activity in the skin. In cystic fibrosis impaired DEFB-4 function can lead to an increased risk of chronic lung infections. The protein's relationship to IL-1 and TNF-alpha plays a role in these inflammatory conditions making DEFB-4 a target of interest for therapeutic research.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854092390569,"sku":"ab70215","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab70215","provider":"Iright","version":"1.0","type":"link"}