{"product_id":"abcam-ab73304","title":"Abcam, ab73304, Anti-LLGL2 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal LLGL2 antibody. Suitable for ELISA, WB, IHC and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human LLGL2.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IHC, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human LLGL2. The exact immunogen used to generate this antibody is proprietary information.Q6P1M3,\u003cbr\u003e\nSpecificity:Reacts specifically with human 113 kDa protein.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purity-Whole antiserum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nLLGL2 also known as Lethal giant larvae homolog 2 is a protein involved in intracellular processes linked with polarity and cell migration. It has an approximate molecular mass of 129 kDa. This protein is encoded by the LLGL2 gene and shares significant homology with other members of the lethal giant larvae family. LLGL2 is widely expressed in various tissues with notable expression in epithelial cells. It interacts with several cytoskeletal components and assists in key protein-protein interactions fundamental for maintaining cellular architecture.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nLLGL2 modulates processes essential for cell polarity growth and proliferation. It is an integral part of the Scribble complex a multi-protein structure that governs cell polarity and tissue architecture. This complex also includes proteins such as Scrib and Dlg which collectively oversee the establishment of distinct cellular domains. LLGL2's ability to regulate epithelial apicobasal polarity is vital for proper tissue formation and maintenance. Additionally LLGL2 plays roles in the regulation of asymmetric cell division influencing cell fate determination.\u003cbr\u003e\nPathways\u003cbr\u003e\nLLGL2 participates in pathways associated with cell polarity and asymmetric cell division. It is no less important in the Hippo signaling pathway which controls organ size by regulating cell proliferation and apoptosis. This pathway involves interactions with proteins like YAP\/TAZ and MST1\/2 which influence cell cycle regulation and growth suppression. Moreover LLGL2's function aligns with the Par complex a critical component of cellular signaling responsible for polarity and asymmetric division often encompassing proteins such as PAR6 and aPKC.\u003cbr\u003e\nLLGL2 shows relevance in cancer and neurological disorders. It has links to breast cancer where its expression or dysfunction may affect tumor progression and metastasis. The protein interacts with other oncogenic or tumor suppressor proteins such as LKB1 highlighting its role in tumorigenesis. Furthermore mutations or alterations in LLGL2 expression can associate with neurodegenerative diseases including forms of epilepsy. These connections underline the importance of LLGL2 in maintaining neurological health.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854394577065,"sku":"ab73304","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab73304","provider":"Iright","version":"1.0","type":"link"}