{"product_id":"abcam-ab76922","title":"Abcam, ab76922, Anti-TAF6 antibody","description":"\u003cp\u003eSize: 100µL\u003cbr\u003e\nRabbit Polyclonal TAF6 antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human TAF6 aa 600 to C-terminus.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human TAF6 aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P49848\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nTAF6 also known as TAFII70 is a component of the transcription factor IID (TFIID) complex with a mass of about 70 kDa. This protein plays an important role in the initiation of gene transcription by RNA polymerase II. It is expressed in various tissues throughout the body. TAF6 interacts with core promoter elements to facilitate the recruitment of other transcriptional machinery components.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nTAF6 functions as part of the larger TFIID complex which is essential for transcription initiation. The TFIID complex assembles at the core promoter and helps in the recognition and binding of sequence-specific DNA sites. TAF6 contributes to the structural integrity and functional specificity of the complex. These interactions are fundamental for maintaining proper gene expression patterns within cells.\u003cbr\u003e\nPathways\u003cbr\u003e\nTAF6 is integral to transcription regulation pathways such as those initiating from the TATA box within promoters. It works closely with other TFIID components like TATA-binding protein (TBP) and TAF1. Through these interactions TAF6 ensures the correct positioning of RNA polymerase II for efficient transcription initiation. Another pathway involving TAF6 is the MAPK signaling pathway where TAF6 can influence transcriptional responses to external signals.\u003cbr\u003e\nAlterations in TAF6 expression or function have been implicated in certain cancers such as colorectal cancer. TAF6 can also interact with p53 a well-known tumor suppressor protein linking it to cancer progression pathways. Mutations or dysregulation of TAF6 may affect p53-mediated stress responses contributing to tumor development and progression.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46853985501353,"sku":"ab76922","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab76922","provider":"Iright","version":"1.0","type":"link"}