{"product_id":"abcam-ab77519","title":"Abcam, ab77519, Anti-MRGX1 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal MRGX1 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human MRGPRX1.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:ICC\/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human MRGPRX1. The exact immunogen used to generate this antibody is proprietary information.Q96LB2\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Stable for 12 months at -20°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nMRGX1 also known as Mas-related G-protein coupled receptor X1 is a protein encoded by the MRGX1 gene. It has a mass of approximately 37 kDa. MRGX1 is primarily expressed in the dorsal root ganglion neurons and plays a significant role in nociception which is the sensory perception of pain. This receptor is involved in modulating pain signals and contributes to sensory neuron regulation. MRGX1 is less expressed in other tissues which indicates a specialized function within the peripheral nervous system.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nMRGX1 is involved in pain sensation and is not part of a larger protein complex. Its role is important in pain perception as it modulates the response of sensory neurons to painful stimuli. MRGX1 affects the response threshold for pain contributing to the transmission of both acute and chronic pain signals. The receptor potentially interacts with various ligands to influence pain pathways suggesting that it could be an attractive target for pain management therapies.\u003cbr\u003e\nPathways\u003cbr\u003e\nMRGX1 engages in the G-protein coupled receptor (GPCR) signaling pathway. It plays a significant role by interacting with signaling molecules that affect neuronal excitability and pain perception. MRGX1 functions alongside proteins such as BAM 8-22 a peptide known to activate this receptor and BAM 8 another peptide associated with MRGX1 signaling. These interactions facilitate a complex regulatory mechanism within the GPCR pathway influencing downstream effects on pain modulation.\u003cbr\u003e\nMRGX1 relates to neuropathic pain and chronic pain conditions. Abnormal MRGX1 expression or function has connections to these pain conditions making it a potential target for therapeutic development. The receptor's interaction with proteins such as BAM 8-22 is significant in the context of pain management as modulating these interactions could offer relief for patients suffering from pain disorders. Understanding the exact role of MRGX1 in these conditions can guide the development of targeted treatments to ameliorate pain symptoms.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854227722409,"sku":"ab77519","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab77519","provider":"Iright","version":"1.0","type":"link"}