{"product_id":"abcam-ab79067","title":"Abcam, ab79067, Anti-JP-4 antibody","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nRabbit Polyclonal JP-4 antibody. Suitable for WB, ICC\/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human JPH4.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Rabbit,\u003cbr\u003e\nClonality:Polyclonal,\u003cbr\u003e\nIsotype:IgG,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human,\u003cbr\u003e\nApplications:WB, ICC\/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Synthetic Peptide within Human JPH4. The exact immunogen used to generate this antibody is proprietary information.Q96JJ6\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-Affinity chromatography purified via peptide column, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nJP-4 also known as Junction Protein-4 is a 45 kDa protein that functions mechanically as a structural component in cellular junctions. It is expressed primarily in epithelial cells and assists in maintaining cell-cell adhesion and integrity. The protein is also seen in neural tissues where it plays a similar role in facilitating intercellular connections.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nJP-4 contributes to cellular communication and tissue stability through its involvement in cell junction assembly. It often forms part of a complex with other junctional proteins enhancing the strength and coordination of cellular connections. This protein stabilizes junctional connections ensuring effective communication between adjacent cells and maintaining tissue homeostasis.\u003cbr\u003e\nPathways\u003cbr\u003e\nCellular adhesion pathways and neural signaling processes incorporate JP-4. It interacts within the cadherin-mediated cell junction pathway associating with proteins such as E-cadherin and beta-catenin and aids in mediating adhesive interactions critical for tissue architecture. Additionally JP-4 involvement in neural pathways suggests a role in synaptic stability and neurotransmitter fluidity.\u003cbr\u003e\nAbnormalities in JP-4 have associations with epithelial barrier dysfunctions and neurodegenerative conditions. In inflammatory bowel disease dysfunctional JP-4 disrupts epithelial barriers impairing digestive system integrity. Its interactions with neural proteins such as synapsin indicate potential links to disorders like Alzheimer's disease where synaptic connections deteriorate.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46854215925929,"sku":"ab79067","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab79067","provider":"Iright","version":"1.0","type":"link"}