{"product_id":"abcam-ab84815","title":"Abcam, ab84815, Anti-CACNA1H antibody [N55\/10]","description":"\u003cp\u003eSize: 100µg\u003cbr\u003e\nMouse Monoclonal CACNA1H antibody. Suitable for WB, IHC-P, IHC-Fr and reacts with Rat, Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Fusion protein corresponding to aa 1000-1300 of CACNA1H, fused to CACNA1H.\u003cbr\u003e\nKey facts\u003cbr\u003e\nHost species:Mouse,\u003cbr\u003e\nClonality:Monoclonal,\u003cbr\u003e\nClone number:N55\/10,\u003cbr\u003e\nIsotype:IgG1,\u003cbr\u003e\nCarrier free:No,\u003cbr\u003e\nReacts with:Human, Mouse, Rat,\u003cbr\u003e\nApplications:IHC-P, IHC-Fr, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,\u003cbr\u003e\nImmunogen:Fusion protein corresponding to aa 1000-1300 of CACNA1H, fused to CACNA1H. The exact immunogen used to generate this antibody is proprietary information.O95180,\u003cbr\u003e\nSpecificity:No cross-reactivity against Cav1.3 and Cav3.1\u003c\/p\u003e\n\n\u003cp\u003eProduct details:\u003cbr\u003e\nThe clone number has been updated from S55-10 to N55\/10, both clone numbers name the same antibody clone.\u003c\/p\u003e\n\n\u003cp\u003eProperties and Storage Information:\u003cbr\u003e\nForm-Liquid, Purification technique-Affinity purification Protein G, Storage buffer-Preservative: 0.09% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze \/ thaw cycle\u003c\/p\u003e\n\n\u003cp\u003eSupplementary Information:\u003cbr\u003e\nThis supplementary information is collated from multiple sources and compiled automatically.\u003cbr\u003e\nCACNA1H also known as Cav3.2 or T-type calcium channel alpha-1H subunit functions as a voltage-dependent calcium channel. The protein plays a role in the influx of calcium ions into cells. It has a molecular mass of approximately 260.7 kDa. CACNA1H expresses most abundantly in the central nervous system although you can also find it in the heart and various other tissues. This channel is part of the larger Cav3 family of T-type calcium channels which includes other subunits like Cav3.1 and Cav3.3.\u003cbr\u003e\nBiological function summary\u003cbr\u003e\nThis calcium channel regulates numerous cellular processes through its role in calcium signaling. It does not form part of a complex but still interacts closely with various signaling molecules to influence activities such as neurotransmitter release and muscle contraction. By modulating membrane potentials and synaptic transmission CACNA1H plays a significant direct role in neuronal excitability and rhythmic activities.\u003cbr\u003e\nPathways\u003cbr\u003e\nCACNA1H interacts within the calcium signaling and neurotransmission pathways. In these pathways it regulates calcium ion homeostasis and neuronal excitability working alongside other channels like L-type and N-type calcium channels. CACNA1H affects the excitation-contraction coupling critical for smooth muscle function interlinking with proteins such as calmodulin that respond to changes in calcium ion concentration.\u003cbr\u003e\nCACNA1H has been linked to epilepsy and neuropathic pain. In epilepsy mutations in CACNA1H can disrupt normal calcium flow affecting neuronal firing patterns and contributing to seizures. Its interaction with other ion channels like SCN1A further influences epileptic manifestations. Mutations may also contribute to neuropathic pain by altering pain threshold and response through its role in pain pathway modifications.\u003c\/p\u003e","brand":"Abcam","offers":[{"title":"Default Title","offer_id":46860497846441,"sku":"ab84815","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/es\/products\/abcam-ab84815","provider":"Iright","version":"1.0","type":"link"}